Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 6:13 p.m.

On Wednesday in MLB, the Milwaukee Brewers are up against the Pittsburgh Pirates.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Pirates Game Info

• Milwaukee Brewers (94-57) vs. Pittsburgh Pirates (75-76)
• Date: Wednesday, September 16, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Brewers.TV

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-130) | PIT: (+110)
• Spread: MIL: -1.5 (+132) | PIT: +1.5 (-160)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Logan Henderson (Brewers) - 10-3, 2.34 ERA vs Jared Jones (Pirates) - 4-6, 4.10 ERA

This contest's pitching matchup is set, as the Brewers will send Logan Henderson (10-3) to the mound, while Jared Jones (4-6) will take the ball for the Pirates. Henderson's team is 9-7-0 against the spread in his starts this season. Henderson's team has a record of 10-3 this season when he starts and they are the favorite on the moneyline. The Pirates are 8-10-0 ATS in Jones' 18 starts with a set spread. The Pirates have been the moneyline underdog in 10 of Jones' starts this season, and they went 5-5 in those matchups.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (52.4%)

Brewers vs Pirates Moneyline

• Looking at the moneyline for Pirates-Brewers, Pittsburgh is the underdog at +110, and Milwaukee is -130 playing on the road.

Brewers vs Pirates Spread

• The Brewers are favored by 1.5 runs on the road versus the Pirates. The Brewers are +132 to cover the spread, while the Pirates are -160.

Brewers vs Pirates Over/Under

• A total of 7.5 runs has been set for the Brewers-Pirates contest on Sept. 16, with the over available at -104 and the under at -118.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have been victorious in 75, or 64.1%, of the 117 contests they have been chosen as favorites in this season.
• Milwaukee has a record of 59-32 in contests when sportsbooks favor them by -130 or more on the moneyline.
• Contests with the Brewers have gone over the total set by sportsbooks in 65 of 150 chances this season.
• The Brewers have an against the spread record of 79-71-0 in 150 games with a line this season.
• The Pirates have been the underdog on the moneyline 71 total times this season. They've gone 31-40 in those games.
• Pittsburgh has a record of 16-24 when playing as a moneyline underdog with odds of +110 or longer (40%).
• The Pirates have played in 149 games with an over/under set, and have combined with opponents to go over the total 77 times (77-68-4).
• The Pirates have covered 48.3% of their games this season, going 72-77-0 against the spread.

Brewers Player Leaders

• Brice Turang has 33 doubles, three triples, 19 home runs and 87 walks while hitting .267. He has an on-base percentage of .368 and a slugging percentage of .444.
• Among qualifying hitters, he ranks 51st in batting average, his on-base percentage ranks 18th, and he is 51st in slugging.
• William Contreras leads Milwaukee in slugging percentage (.420) thanks to 44 extra-base hits. He's batting .272 with an on-base percentage of .342.
• He ranks 37th in batting average, 52nd in on-base percentage and 76th in slugging in MLB.
• Contreras has picked up a hit in five straight games. In his last five games he is batting .350 with a double, three home runs, four walks and 12 RBIs.
• Jake Bauers has 120 hits and an OBP of .393, both of which lead the Brewers this season.
• Bauers has recorded at least one base hit in four straight games. During his last five outings he is hitting .250 with two home runs, a walk and five RBIs.
• Jackson Chourio is batting .289 with a .346 OBP and 67 RBI for Milwaukee this season.

Pirates Player Leaders

• Bryan Reynolds has 36 doubles, two triples, 17 home runs and 84 walks while batting .264. He's slugging .426 with an on-base percentage of .368.
• Including all qualified hitters, he ranks 57th in batting average, while his on-base percentage is 18th and he is 69th in slugging.
• Brandon Lowe paces his team with 141 hits. He has a batting average of .258 while slugging .477 with an on-base percentage of .326.
• He ranks 66th in batting average, 77th in on-base percentage and 26th in slugging percentage in MLB.
• Nick Gonzales has put up an on-base percentage of .370 and a slugging percentage of .395. Both lead the Pirates.
• Ryan O'Hearn has 15 doubles, 18 home runs and 32 walks while batting .266.

Brewers vs Pirates Head to Head

• 9/15/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/6/2026: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/5/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/4/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 8/3/2026: 4-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +136)
• 7/12/2026: 14-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2026: 3-2 PIT (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2026: 7-6 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2026: 5-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/25/2026: 6-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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