Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 1:12 a.m.

The Milwaukee Brewers are among the MLB squads in action on Wednesday, up against the Pittsburgh Pirates.

We've got you covered, in terms of the vital information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Pirates Game Info

• Milwaukee Brewers (94-57) vs. Pittsburgh Pirates (75-76)
• Date: Wednesday, September 16, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Brewers.TV

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-136) | PIT: (+116)
• Spread: MIL: -1.5 (+126) | PIT: +1.5 (-152)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Logan Henderson (Brewers) - 10-3, 2.34 ERA vs Jared Jones (Pirates) - 4-6, 4.10 ERA

The Brewers will give the nod to Logan Henderson (10-3) versus the Pirates and Jared Jones (4-6). Henderson and his team have a record of 9-7-0 against the spread when he starts. Henderson's team has won 76.9% of his starts when they are favored on the moneyline (10-3). The Pirates are 8-10-0 against the spread when Jones starts. The Pirates have been the underdog on the moneyline in 10 of Jones' starts this season, and they went 5-5 in those matchups.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (52%)

Brewers vs Pirates Moneyline

• Looking at the moneyline for Brewers-Pirates, Milwaukee is the favorite at -136, and Pittsburgh is +116 playing at home.

Brewers vs Pirates Spread

• The Brewers are favored by 1.5 runs on the road versus the Pirates. The Brewers are +126 to cover the spread, while the Pirates are -152.

Brewers vs Pirates Over/Under

• The over/under for the Brewers versus Pirates contest on Sept. 16 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have been victorious in 75, or 64.1%, of the 117 contests they have been chosen as favorites in this season.
• This season Milwaukee has come away with a win 52 times in 80 chances when named as a favorite of at least -136 on the moneyline.
• The Brewers and their opponents have gone over in 65 of their 150 games with a total set by sportsbooks this season.
• The Brewers are 79-71-0 against the spread in their 150 games with a line set by sportsbooks this season.
• The Pirates have gone 31-40 in games they were the underdog on the moneyline (winning 43.7% of those games).
• Pittsburgh is 15-19 (winning 44.1% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Pirates have had an over/under set by oddsmakers 149 times, and have combined with opponents to go over the total in 77 of those games (77-68-4).
• The Pirates have gone 72-77-0 ATS this season.

Brewers Player Leaders

• Brice Turang is hitting .267 with 33 doubles, three triples, 19 home runs and 87 walks. He has an on-base percentage of .368 and a slugging percentage of .444.
• Among qualifying hitters, he ranks 51st in batting average, his on-base percentage ranks 18th, and he is 51st in slugging.
• William Contreras leads Milwaukee in slugging percentage (.420) thanks to 44 extra-base hits. He's batting .272 with an on-base percentage of .342.
• He is 37th in batting average, 54th in on-base percentage and 77th in slugging among qualifying hitters.
• Contreras enters this game looking to extend his five-game hit streak. In his last five games he is hitting .350 with a double, three home runs, four walks and 12 RBIs.
• Jake Bauers leads his team in OBP (.393) and total hits (120) this season.
• Bauers has recorded a hit in four straight games. During his last five outings he is hitting .250 with two home runs, a walk and five RBIs.
• Jackson Chourio is batting .289 with a .346 OBP and 67 RBI for Milwaukee this season.

Pirates Player Leaders

• Bryan Reynolds is batting .264 with 36 doubles, two triples, 17 home runs and 84 walks. He's slugging .426 with an on-base percentage of .368.
• Including all qualifying hitters, he ranks 57th in batting average, while his on-base percentage is 18th and he is 69th in slugging.
• Brandon Lowe has racked up 141 hits to pace his team. He has a batting average of .258 while slugging .477 with an on-base percentage of .326.
• Including all qualified hitters, he ranks 66th in batting average, 77th in on-base percentage and 26th in slugging percentage.
• Nick Gonzales has a .370 on-base percentage and a .395 slugging percentage, both team-high numbers for the Pirates.
• Ryan O'Hearn is hitting .266 with 15 doubles, 18 home runs and 32 walks.

Brewers vs Pirates Head to Head

• 9/15/2026: 5-1 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/6/2026: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/5/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/4/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 8/3/2026: 4-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +136)
• 7/12/2026: 14-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2026: 3-2 PIT (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2026: 7-6 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2026: 5-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/25/2026: 6-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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