Mariners vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 9:12 p.m.

Wednesday's slate in the MLB includes a matchup between the Seattle Mariners and the Los Angeles Angels.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Mariners vs Angels Game Info

• Seattle Mariners (70-82) vs. Los Angeles Angels (58-93)
• Date: Wednesday, September 16, 2026
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: ABTV and Mariners.TV

Mariners vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-136) | LAA: (+116)
• Spread: SEA: -1.5 (+126) | LAA: +1.5 (-152)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Mariners vs Angels Probable Starting Pitchers

Probable Pitchers: George Kirby (Mariners) - 9-11, 4.25 ERA vs Yusei Kikuchi (Angels) - 1-5, 4.75 ERA

The Mariners will give the nod to George Kirby (9-11, 4.25 ERA), who is eyeing win No. 10 on the season, and the Angels will turn to Yusei Kikuchi (1-5, 4.75 ERA). Kirby and his team have a record of 9-19-0 against the spread when he starts. Kirby's team has been victorious in 48% of the games he's started as the moneyline favorite with a record of 12-13. The Angels are 4-7-0 ATS in Kikuchi's 11 starts with a set spread. The Angels are 2-6 in Kikuchi's eight starts this season that they were the moneyline underdog.

Mariners vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (56.1%)

Mariners vs Angels Moneyline

• The moneyline numbers for Mariners vs. Angels reveal Seattle as the favorite (-136) and Los Angeles as the underdog (+116) despite being the home team.

Mariners vs Angels Spread

• The Mariners are at the Angels and are favored by 1.5 runs on the spread. The Mariners are +126 to cover the runline, with the Angels being -152.

Mariners vs Angels Over/Under

• Mariners versus Angels, on Sept. 16, has an over/under of 7.5, with the over being -115 and the under -105.

Bet on Seattle Mariners vs. Los Angeles Angels on FanDuel today!

Mariners vs Angels Betting Trends

• The Mariners have been victorious in 56, or 48.7%, of the 115 contests they have been chosen as favorites in this season.
• Seattle has a record of 35-27 in contests when sportsbooks favor them by -136 or more on the moneyline.
• The Mariners and their opponents have hit the over in 80 of their 150 games with a total set by oddsmakers this season.
• The Mariners have posted a record of 55-95-0 against the spread this season.
• The Angels have gone 44-79 in games they were the underdog on the moneyline (winning 35.8% of those games).
• Los Angeles is 31-54 (winning only 36.5% of its games) when playing as a moneyline underdog of +116 or longer.
• The Angels have played in 150 games with a set over/under, and have combined with their opponents to go over the total 61 times (61-86-3).
• The Angels have collected an 80-70-0 record against the spread this season (covering 53.3% of the time).

Mariners Player Leaders

• Randy Arozarena has 149 hits this season and a team-best OBP of .373. He has a .277 batting average and a slugging percentage of .477.
• Among qualifying hitters in baseball, he ranks 30th in batting average, 12th in on-base percentage, and 26th in slugging.
• Arozarena will look for his sixth straight game with a hit in this contest. In his last five games he is batting .391 with a double, three home runs and eight RBIs.
• Josh Naylor has an OPS of .689, fueled by an OBP of .327 and a team-best slugging percentage of .363 this season. He's batting .271.
• He is 41st in batting average, 74th in on-base percentage and 124th in slugging among qualifying batters.
• Cole Young has 136 hits this season and has a slash line of .248/.309/.389.
• Julio Rodriguez is batting .241 with a .301 OBP and 66 RBI for Seattle this season.

Angels Player Leaders

• Zach Neto has totaled 140 hits with a .442 slugging percentage, both team-best numbers for the Angels. He's batting .241 and with an on-base percentage of .321.
• Including all qualifying hitters, he is 96th in batting average, while his on-base percentage is 84th and he is 56th in slugging.
• Mike Trout leads his team with a .379 on-base percentage. He has a batting average of .243 while slugging .427.
• Including all qualifying hitters, his batting average places him 91st, his on-base percentage is ninth, and he is 67th in slugging.
• Vaughn Grissom has 22 doubles, 11 home runs and 28 walks while batting .241.
• Wade Meckler is hitting .297 with 14 doubles, three home runs and 29 walks.

Mariners vs Angels Head to Head

• 9/15/2026: 2-1 LAA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/14/2026: 6-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/2/2026: 1-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/30/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/29/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/5/2026: 8-7 LAA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/4/2026: 1-0 LAA (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/3/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/14/2025: 11-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 9/13/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)

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