Mariners vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 5:12 a.m.

Wednesday's slate in the MLB includes a matchup between the Seattle Mariners and the Los Angeles Angels.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Angels Game Info

• Seattle Mariners (70-82) vs. Los Angeles Angels (58-93)
• Date: Wednesday, September 16, 2026
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: ABTV and Mariners.TV

Mariners vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-138) | LAA: (+118)
• Spread: SEA: -1.5 (+125) | LAA: +1.5 (-150)
• Total: 8.5 -- Over: (+104) | Under: (-128)

Mariners vs Angels Probable Starting Pitchers

Probable Pitchers: George Kirby (Mariners) - 9-11, 4.25 ERA vs Yusei Kikuchi (Angels) - 1-5, 4.75 ERA

The probable pitchers are George Kirby (9-11) for the Mariners and Yusei Kikuchi (1-5) for the Angels. Kirby's team is 9-19-0 against the spread in his starts this season. Kirby's team has a record of 12-13 this season when he starts and they are the favorite on the moneyline. The Angels have a 4-7-0 record against the spread in Kikuchi's starts. The Angels have a 2-6 record in Kikuchi's eight starts this season when they were the moneyline underdog.

Mariners vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (55.5%)

Mariners vs Angels Moneyline

• Los Angeles is the underdog, +118 on the moneyline, while Seattle is a -138 favorite despite being on the road.

Mariners vs Angels Spread

• The Angels are +1.5 on the run line against the Mariners. The Angels are -150 to cover, and the Mariners are +125.

Mariners vs Angels Over/Under

• Mariners versus Angels on Sept. 16 has an over/under of 8.5 runs, with the odds on the over +104 and the under set at -128.

Bet on Seattle Mariners vs. Los Angeles Angels on FanDuel today!

Mariners vs Angels Betting Trends

• The Mariners have been chosen as favorites in 115 games this year and have walked away with the win 56 times (48.7%) in those games.
• Seattle has a record of 33-22 in contests when bookmakers favor them by -138 or more on the moneyline.
• The Mariners and their opponents have gone over in 80 of their 150 games with a total set by sportsbooks this season.
• The Mariners are 55-95-0 against the spread in their 150 games that had a posted line this season.
• The Angels have gone 44-79 in games they were listed as the moneyline underdog (winning 35.8% of those games).
• Los Angeles has a record of 29-52 when it has played as a moneyline underdog with odds of +118 or longer (35.8%).
• The Angels have played in 150 games with an over/under set, and have combined with opponents to go over the total 61 times (61-86-3).
• The Angels are 80-70-0 ATS this season.

Mariners Player Leaders

• Randy Arozarena leads Seattle with an OBP of .373 this season while batting .277 with 61 walks and 100 runs scored. He has a slugging percentage of .477.
• Among qualified hitters in baseball, his batting average ranks 30th, his on-base percentage ranks 12th, and he is 26th in slugging.
• Arozarena hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .391 with a double, three home runs and eight RBIs.
• Josh Naylor has hit 10 homers this season while driving in 50 runs. He's batting .271 this season and slugging .363 with an on-base percentage of .327.
• He is 41st in batting average, 74th in on-base percentage and 123rd in slugging among qualifying batters.
• Cole Young has collected 136 base hits, an OBP of .309 and a slugging percentage of .389 this season.
• Julio Rodriguez has 21 home runs, 66 RBI and a batting average of .241 this season.

Angels Player Leaders

• Zach Neto has accumulated a team-high slugging percentage (.442) while pacing the Angels in hits (140). He's batting .241 and with an on-base percentage of .321.
• Including all qualified players in the big leagues, his batting average places him 97th, his on-base percentage is 84th, and he is 56th in slugging.
• Mike Trout's .379 on-base percentage leads his team. He has a batting average of .243 while slugging .427.
• He is 92nd in batting average, ninth in on-base percentage and 67th in slugging percentage in the majors.
• Vaughn Grissom has 22 doubles, 11 home runs and 28 walks while hitting .241.
• Wade Meckler is batting .297 with 14 doubles, three home runs and 29 walks.

Mariners vs Angels Head to Head

• 9/15/2026: 2-1 LAA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/14/2026: 6-4 LAA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/2/2026: 1-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/30/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/29/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/5/2026: 8-7 LAA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/4/2026: 1-0 LAA (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/3/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/14/2025: 11-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 9/13/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)

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