Yankees vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 7

Odds updated as of 4:16 p.m.

The New York Yankees are among the MLB teams in action on Wednesday, up against the San Diego Padres.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs Padres Game Info

• New York Yankees (20-16) vs. San Diego Padres (23-12)
• Date: Wednesday, May 7, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: MLB Network, Amazon Prime Video, and SDPA

Yankees vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-184) | SD: (+154)
• Spread: NYY: -1.5 (+112) | SD: +1.5 (-134)
• Total: 8 -- Over: (-106) | Under: (-114)

Yankees vs Padres Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 6-0, 1.01 ERA vs Dylan Cease (Padres) - 1-2, 5.61 ERA

This contest's pitching matchup is set, as the Yankees will send Max Fried (6-0) to the mound, while Dylan Cease (1-2) will take the ball for the Padres. Fried's team is 6-1-0 against the spread in his starts this season. Fried and his team have won each of the seven games he's started as the moneyline favorite. The Padres have gone 3-4-0 against the spread when Cease starts. The Padres were named the moneyline underdog for one Cease start this season -- they won.

Yankees vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (50%)

Yankees vs Padres Moneyline

• New York is the favorite, -184 on the moneyline, while San Diego is a +154 underdog on the road.

Yankees vs Padres Spread

• The Padres are at the Yankees, and are +1.5 on the runline. The Padres are +112 to cover the spread, and the Yankees are -134.

Yankees vs Padres Over/Under

• A total of 8 runs has been set for the Yankees-Padres contest on May 7, with the over available at -106 and the under at -114.

Bet on New York Yankees vs. San Diego Padres on FanDuel today!

Yankees vs Padres Betting Trends

• The Yankees have been chosen as favorites in 29 games this year and have walked away with the win 18 times (62.1%) in those games.
• This season New York has come away with a win three times in four chances when named as a favorite of at least -184 on the moneyline.
• The Yankees and their opponents have gone over in 16 of their 35 games with a total set by sportsbooks this season.
• The Yankees are 17-18-0 against the spread in their 35 games that had a posted line this season.
• The Padres have compiled an 8-8 record in games they were the underdog on the moneyline (winning 50% of those games).
• San Diego has not yet played as a moneyline underdog of +154 or longer.
• In the 34 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total 14 times (14-19-1).
• The Padres have a 20-14-0 record ATS this season.

Yankees Player Leaders

• Aaron Judge leads New York in OBP (.503), slugging percentage (.772) and total hits (56) this season. He has a .412 batting average.
• Among qualifying batters in the majors, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Paul Goldschmidt is batting .351 with eight doubles, three home runs and 11 walks. He's slugging .478 with an on-base percentage of .401.
• He ranks second in batting average, eighth in on-base percentage and 36th in slugging in MLB.
• Ben Rice is batting .264 with a .573 slugging percentage and 15 RBI this year.
• Rice heads into this matchup with two games in a row with at least one hit. During his last five outings he is batting .250 with four doubles, a walk and two RBIs.
• Trent Grisham is batting .284 with a .370 OBP and 18 RBI for New York this season.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated 42 hits with a .388 on-base percentage and a .557 slugging percentage, all club-highs for the Padres. He's batting .321.
• Including all qualifying hitters in MLB, he is seventh in batting average, 18th in on-base percentage and 12th in slugging percentage.
• Manny Machado is hitting .300 with 12 doubles, three home runs and 13 walks. He's slugging .462 with an on-base percentage of .361.
• Including all qualified hitters, his batting average puts him 20th, his on-base percentage ranks 47th, and he is 46th in slugging.
• Luis Arraez is batting .289 with four doubles, a triple, three home runs and seven walks.
• Xander Bogaerts is hitting .246 with nine doubles, a home run and 16 walks.

Yankees vs Padres Head to Head

• 5/6/2025: 12-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/5/2025: 4-3 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/26/2024: 5-2 SD (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/25/2024: 4-1 NYY (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/24/2024: 8-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/28/2023: 10-7 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/27/2023: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/26/2023: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)

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