Yankees vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for March 25

Odds updated as of 8:12 p.m.

MLB Opening Day on Wednesday features the New York Yankees facing the San Francisco Giants.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Giants Game Info

• New York Yankees (0-0) vs. San Francisco Giants (0-0)
• Date: Wednesday, March 25, 2026
• Time: 8:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: Netflix

Yankees vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-122) | SF: (+104)
• Spread: NYY: -1.5 (+146) | SF: +1.5 (-176)
• Total: 7 -- Over: (-115) | Under: (-105)

Yankees vs Giants Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 0-0, 0.00 ERA vs Logan Webb (Giants) - 0-0, 0.00 ERA

The Yankees will call on Max Fried versus the Giants and Logan Webb. In games Fried pitched with a spread last season, his team was 19-15-0 ATS. Fried and his team won as favorites in 64.7% of his 34 appearances last season with a moneyline. Last season in games Webb pitched his team finished 16-18-0 against the spread. Webb and his team went 3-1 in games he appeared in when they were moneyline underdogs a season ago.

Yankees vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (52.7%)

Yankees vs Giants Moneyline

• San Francisco is the underdog, +104 on the moneyline, while New York is a -122 favorite despite being on the road.

Yankees vs Giants Spread

• The Giants are hosting the Yankees, and are +1.5 on the runline. The Giants are +146 to cover the spread, and the Yankees are -176.

Yankees vs Giants Over/Under

• The over/under for the Yankees versus Giants game on March 25 has been set at 7, with -115 odds on the over and -105 odds on the under.

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Yankees vs Giants Betting Trends

• The Yankees came away with 88 wins in the 143 contests they were listed as the favorites last season.
• Last year, New York won 83 of 133 games when listed as at least -122 on the moneyline.
• The Yankees and their opponents hit the over in 79 of their 166 games with a total last season.
• The Giants put together a 29-36 record in games last season when they were listed as the moneyline underdog (winning 44.6% of those games).
• San Francisco went 21-28 when it played as a moneyline underdog with odds of +104 or longer (42.9%).
• The Giants combined with their opponents to hit the over on the total 77 times last season for a 77-76-8 record against the over/under.

Yankees Player Leaders

• Aaron Judge had 179 base hits and an OBP of .457 to go with a slugging percentage of .688 last season.
• Cody Bellinger slashed .272/.334/.480 and finished with an OPS of .813.
• Trent Grisham ended his last campaign with 116 hits, an OBP of .348, plus a slugging percentage of .465.
• Ben Rice slashed .255/.337/.499 and finished with an OPS of .836.

Giants Player Leaders

• Rafael Devers put up an OBP of .372 with 153 hits last season.
• Luis Arraez slugged .392 while batting .292.
• Willy Adames had 22 doubles, two triples, 30 home runs and 80 walks while batting .225 last season.
• Jung Hoo Lee hit .266 with 31 doubles, 12 triples, eight home runs and 47 walks.

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