Yankees vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 6:14 p.m.

MLB action on Saturday includes the New York Yankees facing the Houston Astros.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs Astros Game Info

• New York Yankees (17-9) vs. Houston Astros (10-17)
• Date: Saturday, April 25, 2026
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and YES

Yankees vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-154) | HOU: (+130)
• Spread: NYY: -1.5 (+106) | HOU: +1.5 (-128)
• Total: 9 -- Over: (-118) | Under: (-104)

Yankees vs Astros Probable Starting Pitchers

Probable Pitchers: Ryan Weathers (Yankees) - 1-2, 3.18 ERA vs Mike Burrows (Astros) - 1-3, 6.75 ERA

The Yankees will call on Ryan Weathers (1-2) against the Astros and Mike Burrows (1-3). Weathers and his team have a record of 1-3-0 against the spread when he starts. When Weathers starts a game and his team is the favorite on the moneyline, they have a record of 1-3. The Astros have gone 1-4-0 against the spread when Burrows starts. The Astros were the moneyline underdog for two Burrows starts this season -- they split the games.

Yankees vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (51.4%)

Yankees vs Astros Moneyline

• Houston is a +130 underdog on the moneyline, while New York is a -154 favorite on the road.

Yankees vs Astros Spread

• The Yankees are at the Astros and are favored by 1.5 runs on the spread. The Yankees are +106 to cover the runline, with the Astros being -128.

Yankees vs Astros Over/Under

• Yankees versus Astros on April 25 has an over/under of 9 runs, with the odds on the over -118 and the under set at -104.

Bet on New York Yankees vs. Houston Astros on FanDuel today!

Yankees vs Astros Betting Trends

• The Yankees have won in 14, or 63.6%, of the 22 contests they have been named as odds-on favorites in this year.
• This season New York has come away with a win eight times in 13 chances when named as a favorite of at least -154 on the moneyline.
• The Yankees and their opponents have hit the over in nine of their 24 games with a total set by oddsmakers this season.
• The Yankees are 14-10-0 against the spread in their 24 games with a line set by sportsbooks this season.
• The Astros have won four of the 10 games they were the underdog on the moneyline this season (40%).
• When it has played as a moneyline underdog with odds of +130 or longer, Houston has a 1-2 record (winning just 33.3% of its games).
• The Astros have combined with opponents to go over the total 19 times this season for a 19-8-0 record against the over/under.
• The Astros have covered just 37% of their games this season, going 10-17-0 against the spread.

Yankees Player Leaders

• Ben Rice leads New York in OBP (.450), slugging percentage (.747) and total hits (25) this season. He has a .316 batting average.
• Among qualified batters, he is 15th in batting average, his on-base percentage ranks second, and he is second in slugging.
• Rice will look for his third straight game with a hit in this matchup. During his last five outings he is hitting .235 with a double, two home runs, three walks and three RBIs.
• Aaron Judge has three doubles, nine home runs and 19 walks. He's batting .237 and slugging .559 with an on-base percentage of .372.
• He is 106th in batting average, 28th in on-base percentage and 13th in slugging among qualifying hitters.
• Cody Bellinger has collected 24 base hits, an OBP of .364 and a slugging percentage of .422 this season.
• Bellinger heads into this game with two games in a row with at least one hit. During his last five outings he is batting .235 with a double, three walks and two RBIs.
• Trent Grisham has three home runs, 15 RBI and a batting average of .162 this season.

Astros Player Leaders

• Yordan Alvarez has accumulated an on-base percentage of .471, a slugging percentage of .776, and has 35 hits, all club-bests for the Astros (while batting .357).
• Including all the qualified players in the big leagues, he ranks first in batting average, first in on-base percentage and first in slugging percentage.
• Alvarez hopes to build on a 10-game hitting streak in this matchup. During his last 10 outings he is hitting .405 with four doubles, five home runs, three walks and 12 RBIs.
• Christian Walker is batting .274 with seven doubles, five home runs and 13 walks. He's slugging .505 with an on-base percentage of .364.
• He is currently 49th in batting average, 37th in on-base percentage and 30th in slugging percentage among all qualified hitters.
• Jose Altuve has seven doubles, three home runs and 15 walks while hitting .267.
• Carlos Correa is hitting .275 with six doubles, a home run and 12 walks.

Yankees vs Astros Head to Head

• 4/24/2026: 12-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/4/2025: 8-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/3/2025: 8-7 HOU (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/2/2025: 7-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/10/2025: 7-1 HOU (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/9/2025: 5-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/8/2025: 5-3 HOU (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/9/2024: 4-3 HOU (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/8/2024: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/7/2024: 10-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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