White Sox vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 3:12 p.m.

In MLB action on Saturday, the Chicago White Sox face the Washington Nationals.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

White Sox vs Nationals Game Info

• Chicago White Sox (11-15) vs. Washington Nationals (11-16)
• Date: Saturday, April 25, 2026
• Time: 4:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and Nationals.TV

White Sox vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-144) | WSH: (+122)
• Spread: CHW: -1.5 (+140) | WSH: +1.5 (-170)
• Total: 8.5 -- Over: (+100) | Under: (-122)

White Sox vs Nationals Probable Starting Pitchers

Probable Pitchers: Noah Schultz (White Sox) - 1-1, 3.86 ERA vs Jake Irvin (Nationals) - 1-3, 6.00 ERA

The White Sox will give the nod to Noah Schultz (1-1, 3.86 ERA), who is eyeing win No. 2 on the season, and the Nationals will counter with Jake Irvin (1-3, 6.00 ERA). Schultz has a record of 1-1-0 ATS in two starts with a spread this season. This will be Schultz's first game as the moneyline favorite this season. The Nationals have gone 2-3-0 against the spread when Irvin starts. The Nationals are 2-3 in Irvin's five starts this season that they were the moneyline underdog.

White Sox vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (55.7%)

White Sox vs Nationals Moneyline

• Washington is a +122 underdog on the moneyline, while Chicago is a -144 favorite at home.

White Sox vs Nationals Spread

• The Nationals are at the White Sox, and are +1.5 on the runline. The Nationals are +140 to cover the spread, and the White Sox are -170.

White Sox vs Nationals Over/Under

• White Sox versus Nationals on April 25 has an over/under of 8.5 runs, with the odds on the over +100 and the under set at -122.

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White Sox vs Nationals Betting Trends

• The White Sox came away victorious in the one game they played as the favorite this season.
• Chicago has not played a game this season with better moneyline odds than -144.
• The White Sox's games have gone over the total in 15 of their 25 opportunities.
• The White Sox have posted a record of 12-13-0 against the spread this season.
• The Nationals have won 11 of the 26 games they were the moneyline underdog this season (42.3%).
• Washington has a 9-11 record (winning 45% of its games) when it has played as a moneyline underdog of +122 or longer.
• In the 27 games bookmakers have set an over/under for the Nationals, they have combined with opponents to go over the total 18 times (18-8-1).
• The Nationals have gone 15-12-0 against the spread this season.

White Sox Player Leaders

• Munetaka Murakami leads Chicago in OBP (.398), slugging percentage (.622) and total hits (23) this season. He has a .256 batting average.
• Among qualified hitters in baseball, he is 73rd in batting average, 14th in on-base percentage, and third in slugging.
• Murakami hopes to build on a seven-game hitting streak in this matchup. In his last 10 outings he is batting .385 with seven home runs, nine walks and 13 RBIs.
• Miguel Vargas is hitting .209 with three doubles, a triple, five home runs and 17 walks. He's slugging .429 with an on-base percentage of .342.
• His batting average ranks 152nd among qualified players, his on-base percentage 72nd, and his slugging percentage 70th.
• Vargas has picked up a hit in five straight games. During his last five outings he is batting .421 with three home runs, five walks and five RBIs.
• Colson Montgomery is batting .239 with a .522 slugging percentage and 19 RBI this year.
• Montgomery heads into this game with seven games in a row with at least one hit. During his last 10 outings he is batting .297 with two doubles, four home runs, five walks and 10 RBIs.
• Chase Meidroth has an OPS of .680, fueled by an OBP of .340 and a team-best slugging percentage of .341 this season.

Nationals Player Leaders

• James Wood has racked up an on-base percentage of .409 and has 26 hits, both team-high numbers for the Nationals. He's batting .250 and slugging .596.
• Including all qualified players in MLB, his batting average places him 79th, his on-base percentage ranks 12th, and he is fourth in slugging.
• C.J. Abrams is hitting .280 with three doubles, seven home runs and 13 walks. He's slugging .538 with an on-base percentage of .398.
• He is 41st in batting average, 14th in on-base percentage and 20th in slugging percentage in MLB.
• Daylen Lile has accumulated a slugging percentage of .444, a team-best for the Nationals.
• Luis Garcia is hitting .259 with five doubles, a triple, a home run and four walks.

White Sox vs Nationals Head to Head

• 4/24/2026: 5-4 CHW (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/28/2025: 8-0 CHW (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/27/2025: 6-5 WSH (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/26/2025: 10-9 CHW (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/15/2024: 2-0 CHW (Favorite: White Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/14/2024: 4-0 CHW (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2024: 6-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/20/2023: 13-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 9/19/2023: 4-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/18/2023: 6-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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