Blue Jays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 9:12 p.m.

MLB action on Saturday includes the Toronto Blue Jays taking on the Cleveland Guardians.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Guardians Game Info

• Toronto Blue Jays (10-14) vs. Cleveland Guardians (14-12)
• Date: Saturday, April 25, 2026
• Time: 3:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: Fox Sports 1, SN1, and CleGuardians.TV

Blue Jays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-134) | CLE: (+116)
• Spread: TOR: -1.5 (+158) | CLE: +1.5 (-192)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Blue Jays vs Guardians Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Blue Jays) - 1-1, 2.86 ERA vs Joey Cantillo (Guardians) - 1-0, 3.20 ERA

The Blue Jays will give the ball to Kevin Gausman (1-1, 2.86 ERA), who is eyeing win No. 2 on the season, and the Guardians will counter with Joey Cantillo (1-0, 3.20 ERA). Gausman and his team are 2-3-0 ATS this season when he starts. Gausman's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. The Guardians have a 4-1-0 ATS record in Cantillo's five starts that had a set spread. The Guardians won each of Cantillo's three starts this season that they were the moneyline underdog.

Blue Jays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (62.1%)

Blue Jays vs Guardians Moneyline

• Toronto is a -134 favorite on the moneyline, while Cleveland is a +116 underdog on the road.

Blue Jays vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Blue Jays. The Guardians are -192 to cover the spread, and the Blue Jays are +158.

Blue Jays vs Guardians Over/Under

• A combined run total of 7.5 has been set for Blue Jays-Guardians on April 25, with the over at -115 and the under at -105.

Bet on Toronto Blue Jays vs. Cleveland Guardians on FanDuel today!

Blue Jays vs Guardians Betting Trends

• The Blue Jays have been chosen as favorites in 15 games this year and have walked away with the win seven times (46.7%) in those games.
• Toronto has a record of 5-6 when favored by -134 or more this year.
• The Blue Jays and their opponents have gone over in 12 of their 24 games with a total set by sportsbooks this season.
• In 24 games with a line this season, the Blue Jays have a mark of 8-16-0 against the spread.
• The Guardians have won eight of the 15 games they were listed as the moneyline underdog this season (53.3%).
• Cleveland has a record of 4-5 when playing as a moneyline underdog with odds of +116 or longer (44.4%).
• The Guardians have combined with opponents to go over the total 13 times this season for a 13-13-0 record against the over/under.
• The Guardians have a 15-11-0 record ATS this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has 30 hits and an OBP of .427, both of which lead Toronto hitters this season. He has a .337 batting average and a slugging percentage of .461.
• Among all qualified hitters in the majors, he ranks third in batting average, third in on-base percentage, and 47th in slugging.
• Andres Gimenez is hitting .267 with four doubles, a triple, three home runs and four walks. He's slugging .442 with an on-base percentage of .297.
• He ranks 53rd in batting average, 135th in on-base percentage and 63rd in slugging in the major leagues.
• Ernie Clement has an OPS of .747, fueled by an OBP of .327 and a team-best slugging percentage of .420 this season.
• Clement enters this game with seven games in a row with at least one hit. In his last 10 outings he is batting .364 with six doubles and two RBIs.
• Daulton Varsho is batting .263 with a .333 OBP and seven RBI for Toronto this season.
• Varsho enters this game on a two-game hitting streak. During his last five outings he is batting .250 with .

Guardians Player Leaders

• Jose Ramirez has put up a slugging percentage of .479, a team-high for the Guardians. He's batting .234 with an on-base percentage of .363.
• Including all qualified players in the big leagues, he ranks 115th in batting average, 42nd in on-base percentage and 43rd in slugging percentage.
• Ramirez hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .294 with a double, two home runs, four walks and two RBIs.
• Chase DeLauter leads his team with 19 hits. He has a batting average of .235 while slugging .506 with an on-base percentage of .330.
• He ranks 114th in batting average, 92nd in on-base percentage and 32nd in slugging percentage in the majors.
• Brayan Rocchio has put up an on-base percentage of .367, a team-high for the Guardians.
• Steven Kwan leads his team with a .289 slugging percentage.

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