Blue Jays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 2:11 p.m.

The MLB's Saturday schedule includes the Toronto Blue Jays taking on the Cleveland Guardians.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Guardians Game Info

• Toronto Blue Jays (10-15) vs. Cleveland Guardians (15-12)
• Date: Saturday, April 25, 2026
• Time: 3:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: Fox Sports 1, SN1, and CleGuardians.TV

Blue Jays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-156) | CLE: (+132)
• Spread: TOR: -1.5 (+138) | CLE: +1.5 (-166)
• Total: 7 -- Over: (-110) | Under: (-110)

Blue Jays vs Guardians Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Blue Jays) - 1-1, 2.86 ERA vs Joey Cantillo (Guardians) - 1-0, 3.20 ERA

The probable pitchers are Kevin Gausman (1-1) for the Blue Jays and Joey Cantillo (1-0) for the Guardians. When Gausman starts, his team is 2-3-0 against the spread this season. Gausman's team has won 66.7% of his starts when they are favored on the moneyline (2-1). The Guardians have a 4-1-0 ATS record in Cantillo's five starts that had a set spread. The Guardians were named the moneyline underdog for three Cantillo starts this season -- they won all of the games.

Blue Jays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (60.8%)

Blue Jays vs Guardians Moneyline

• Toronto is a -156 favorite on the moneyline, while Cleveland is a +132 underdog on the road.

Blue Jays vs Guardians Spread

• The Guardians are +1.5 on the spread (-166 to cover), and Toronto is +138 to cover the runline.

Blue Jays vs Guardians Over/Under

• A combined run total of 7 has been set for Blue Jays-Guardians on April 25, with the over at -110 and the under at -110.

Bet on Toronto Blue Jays vs. Cleveland Guardians on FanDuel today!

Blue Jays vs Guardians Betting Trends

• The Blue Jays have won in seven, or 46.7%, of the 15 contests they have been named as odds-on favorites in this year.
• This season Toronto has been victorious three times in seven chances when named as a favorite of at least -156 on the moneyline.
• The Blue Jays and their opponents have gone over the total this season in 13 of their 25 opportunities.
• In 25 games with a line this season, the Blue Jays have a mark of 8-17-0 against the spread.
• The Guardians have an 8-7 record in games they were listed as the moneyline underdog (winning 53.3% of those games).
• Cleveland is 4-3 (winning 57.1% of its games) when playing as a moneyline underdog of +132 or longer.
• The Guardians have played in 27 games with an over/under set, and have combined with opponents to go over the total 14 times (14-13-0).
• The Guardians are 16-11-0 ATS this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto with an OBP of .411 this season while batting .323 with 13 walks and 13 runs scored. He has a slugging percentage of .441.
• Among qualifying hitters, he is eighth in batting average, his on-base percentage ranks 10th, and he is 62nd in slugging.
• Andres Gimenez leads Toronto with 26 hits. He is batting .289 this season and has nine extra-base hits. He's also slugging .467 with an on-base percentage of .316.
• He ranks 30th in batting average, 118th in on-base percentage and 50th in slugging in the major leagues.
• Gimenez brings a two-game streak with at least one hit into this one. During his last five outings he is hitting .353 with two doubles and three RBIs.
• Ernie Clement has hit zero homers with a team-high .423 SLG this season.
• Clement has logged a hit or more in eight games in a row. In his last 10 outings he is hitting .326 with six doubles and three RBIs.
• Jesus Sanchez has been key for Toronto with 20 hits, an OBP of .325 plus a slugging percentage of .432.
• Sanchez enters this matchup on a three-game hitting streak. During his last five outings he is hitting .308 with a home run, two walks and an RBI.

Guardians Player Leaders

• Jose Ramirez has put up a team-high .469 slugging percentage. He's batting .235 with an on-base percentage of .364.
• Including all the qualifying hitters in the big leagues, his batting average ranks 108th, his on-base percentage is 35th, and he is 49th in slugging.
• Ramirez hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .316 with a double, two home runs, four walks and two RBIs.
• Chase DeLauter paces his team with 19 hits. He has a batting average of .224 while slugging .482 with an on-base percentage of .323.
• Including all qualifying hitters, his batting average puts him 131st, his on-base percentage is 105th, and he is 40th in slugging.
• Brayan Rocchio has put up an on-base percentage of .372 and a slugging percentage of .427. Both lead the Guardians.
• Angel Martinez is hitting .284 with four doubles, five home runs and three walks.

Blue Jays vs Guardians Head to Head

• 4/24/2026: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/26/2025: 6-0 TOR (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/25/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/24/2025: 10-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/4/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/3/2025: 5-3 CLE (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/2/2025: 5-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/23/2024: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/22/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/21/2024: 7-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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