White Sox vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 24

Odds updated as of 9:11 a.m.

MLB action on Friday includes the Chicago White Sox taking on the Washington Nationals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

White Sox vs Nationals Game Info

• Chicago White Sox (10-15) vs. Washington Nationals (11-15)
• Date: Friday, April 24, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and Nationals.TV

White Sox vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-122) | WSH: (+104)
• Spread: CHW: +1.5 (-200) | WSH: -1.5 (+164)
• Total: 9.5 -- Over: (+100) | Under: (-122)

White Sox vs Nationals Probable Starting Pitchers

Probable Pitchers: Bryan Hudson (White Sox) - 0-0, 1.69 ERA vs Miles Mikolas (Nationals) - 0-3, 9.15 ERA

The White Sox will give the nod to Bryan Hudson and the Nationals will turn to Miles Mikolas (0-3, 9.15 ERA). Hudson did not pitch in a game with a spread last season. Hudson did not appear in a game when his team was the moneyline favorite last season. In all of Mikolas' three starts that had a set spread, the Nationals failed to cover. The Nationals were named the moneyline underdog for three Mikolas starts this season -- they lost every time.

White Sox vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (56.7%)

White Sox vs Nationals Moneyline

• Looking at the moneyline for White Sox-Nationals, Chicago is the favorite at -122, and Washington is +104 playing on the road.

White Sox vs Nationals Spread

• The Nationals are 1.5-run favorites against the spread for this matchup with the White Sox. The Nationals are +164 to cover, while the White Sox are -200 to cover as a 1.5-run underdog on the runline.

White Sox vs Nationals Over/Under

• A combined run total of 9.5 has been set for White Sox-Nationals on April 24, with the over at +100 and the under at -122.

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White Sox vs Nationals Betting Trends

• The White Sox have yet to play a game this season while listed as the odds-on favorite.
• Oddsmakers have given Chicago the best odds of winning it has seen this season, with a -122 moneyline listed for this contest.
• The White Sox's games have gone over the total in 15 of their 24 opportunities.
• The White Sox are 11-13-0 against the spread in their 24 games that had a posted line this season.
• The Nationals have won 44% of the games this season they were the moneyline underdog (11-14).
• In games it has played as a moneyline underdog with odds of +104 or longer, Washington has a record of 10-13 (43.5%).
• The Nationals have had an over/under set by oddsmakers 26 times, and have combined with opponents to go over the total in 18 of those games (18-7-1).
• The Nationals have a 15-11-0 record against the spread this season (covering 57.7% of the time).

White Sox Player Leaders

• Munetaka Murakami has 22 hits and an OBP of .394, both of which are tops among Chicago hitters this season. He has a .253 batting average and a slugging percentage of .598.
• Among the qualified batters in the majors, his batting average ranks 77th, his on-base percentage ranks 17th, and he is seventh in slugging.
• Murakami has recorded a base hit in six games in a row. In his last 10 games he is batting .359 with six home runs, 10 walks and 12 RBIs.
• Miguel Vargas is batting .195 with three doubles, a triple, five home runs and 17 walks, while slugging .425 with an on-base percentage of .336.
• His batting average ranks 157th among qualified players, his on-base percentage 85th, and his slugging percentage 74th.
• Vargas brings a four-game streak with at least one hit into this contest. During his last five outings he is batting .316 with three home runs, seven walks and five RBIs.
• Colson Montgomery has 21 hits this season and has a slash line of .236/.333/.528.
• Montgomery takes a six-game hitting streak into this game. In his last 10 games he is hitting .324 with three doubles, five home runs, four walks and 11 RBIs.
• Chase Meidroth leads Chicago in slugging percentage (.356) thanks to six extra-base hits.
• Meidroth has safely hit in eight games in a row. During his last 10 games he is batting .316 with two doubles and six walks.

Nationals Player Leaders

• James Wood paces the Nationals with 26 hits. He's batting .255 and slugging .608 with an on-base percentage of .402.
• Including all qualified hitters, he is 74th in batting average, while his on-base percentage is 13th and he is fourth in slugging.
• Wood enters this game on a three-game hitting streak. During his last five outings he is hitting .250 with three home runs, seven walks and three RBIs.
• C.J. Abrams has a .413 on-base percentage to pace his team. He has a batting average of .292 while slugging .562.
• He ranks 29th in batting average, ninth in on-base percentage and 15th in slugging percentage in the big leagues.
• Daylen Lile has accumulated a slugging percentage of .448, a team-high for the Nationals.
• Luis Garcia has four doubles, a triple, a home run and four walks while batting .244.

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