USC vs TCU Prediction, Odds, Picks, Best Bets for Alamo Bowl 2025

College football's Tuesday schedule includes the USC Trojans taking on the TCU Horned Frogs.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information about today's NCAA football betting odds.

USC vs TCU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-205) | TCU: (+172)
• Spread: USC: -5.5 (-110) | TCU: +5.5 (-110)
• Total: 56.5 -- Over: (-110) | Under: (-110)

USC vs TCU Betting Trends

• USC is 5-7-0 against the spread this season.
• As 5.5-point favorites or more, USC is 3-5 against the spread.
• This year, six of USC's 12 games have hit the over.
• TCU is 6-6-0 against the spread this season.
• There have been six TCU games (out of 12) that hit the over this year.

USC vs TCU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (75.4%)

USC vs TCU Point Spread

USC is a 5.5-point favorite against TCU. USC is -110 to cover the spread, and TCU is -110.

USC vs TCU Over/Under

A combined point total of 56.5 has been set for USC-TCU on Dec. 30, with the over at -110 and the under at -110.

USC vs TCU Moneyline

The USC vs TCU moneyline has USC as a -205 favorite, while TCU is a +172 underdog.

USC vs. TCU Points Insights

USC vs. TCU Game Info

• Game day: Tuesday, December 30, 2025
• Game time: 9 p.m. ET
• TV channel: ESPN
• Location: San Antonio, Texas
• Stadium: Alamodome

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Check out even more in-depth USC vs. TCU analysis on FanDuel Research.