USC vs Nebraska Prediction, Odds, Picks, Best Bets for Week 10 2025

The USC Trojans versus the Nebraska Cornhuskers is on the college football schedule for Saturday.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

USC vs Nebraska Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-196) | Nebraska: (+164)
• Spread: USC: -4.5 (-114) | Nebraska: +4.5 (-106)
• Total: 58.5 -- Over: (-115) | Under: (-105)

USC vs Nebraska Betting Trends

• USC has covered the spread four times in seven games.
• USC has won twice ATS (2-3) as a 4.5-point or bigger favorite this season.
• Out of seven USC games so far this season, four have gone over the total.
• Nebraska has won twice against the spread this year.
• This year, six of Nebraska's eight games have hit the over.

USC vs Nebraska Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (65.7%)

USC vs Nebraska Point Spread

Nebraska is the underdog by 4.5 points against USC. Nebraska is -114 to cover the spread, and USC is -106.

USC vs Nebraska Over/Under

A total of 58.5 points has been set for the USC-Nebraska matchup on Nov. 1, with the over available at -115 and the under at -105.

USC vs Nebraska Moneyline

USC is a -196 favorite on the moneyline, while Nebraska is a +164 underdog.

USC vs. Nebraska Points Insights

USC vs. Nebraska Game Info

• Game day: Saturday, November 1, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Lincoln, Nebraska
• Stadium: Memorial Stadium (Lincoln, NE)

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Check out even more in-depth USC vs. Nebraska analysis on FanDuel Research.