USC vs Missouri State Prediction, Odds, Picks, Best Bets for Week 1 2025

The college football slate on Saturday includes the USC Trojans taking on the Missouri State Bears.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

USC vs Missouri State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-33333) | Missouri State: (+4000)
• Spread: USC: -36.5 (-110) | Missouri State: +36.5 (-110)
• Total: 59.5 -- Over: (-115) | Under: (-105)

USC vs Missouri State Betting Trends

• USC was 8-5-0 against the spread last year.
• Last season, six of USC's 13 games hit the over.
• Against the spread, Missouri State was 5-6-0 last season.
• Last year, seven of Missouri State's 11 games hit the over.

USC vs Missouri State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (97.7%)

USC vs Missouri State Point Spread

USC is a 36.5-point favorite against Missouri State. USC is -110 to cover the spread, and Missouri State is -110.

USC vs Missouri State Over/Under

USC versus Missouri State, on Aug. 30, has an over/under of 59.5, with the over being -115 and the under -105.

USC vs Missouri State Moneyline

The USC vs Missouri State moneyline has USC as a -33333 favorite, while Missouri State is a +4000 underdog.

USC vs. Missouri State Points Insights

• The average implied total for the Trojans last season was 31.2 points, 16.8 fewer points than their implied total of 48 points in Saturday's game.
• The 34.2-point average implied total last season for the Bears is 22.2 more points than the team's 12-point implied total in this matchup.

USC vs. Missouri State Game Info

• Game day: Saturday, August 30, 2025
• Game time: 7:30 p.m. ET
• TV channel: BTN
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth USC vs. Missouri State analysis on FanDuel Research.