UConn vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 3 2026

The UConn Huskies are among the college football squads busy on Saturday, versus the Southern Miss Golden Eagles.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

UConn vs Southern Miss Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: UConn: (-166) | Southern Miss: (+138)
• Spread: UConn: -3.5 (-102) | Southern Miss: +3.5 (-120)
• Total: 54.5 -- Over: (-110) | Under: (-110)

UConn vs Southern Miss Betting Trends

• UConn has posted one win against the spread this year.
• UConn has covered every time (1-0) as a 3.5-point favorite or greater this year.
• UConn has had one game (of two) hit the over this season.
• Southern Miss has but one win versus the spread this year.
• Southern Miss has no wins ATS (0-1) as a 3.5-point underdog or greater this season.
• Southern Miss has had one game (of two) go over the total this season.

UConn vs Southern Miss Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Huskies win (61.5%)

UConn vs Southern Miss Point Spread

UConn is favored by 3.5 points over Southern Miss. UConn is -102 to cover the spread, with Southern Miss being -120.

UConn vs Southern Miss Over/Under

The over/under for the UConn versus Southern Miss matchup on Sept. 19 has been set at 54.5, with -110 odds on the over and -110 odds on the under.

UConn vs Southern Miss Moneyline

Southern Miss is the underdog, +138 on the moneyline, while UConn is a -166 favorite.

UConn vs. Southern Miss Points Insights

UConn vs. Southern Miss Game Info

• Game day: Saturday, September 19, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN+
• Location: Hattiesburg, Mississippi
• Stadium: M.M. Roberts Stadium

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Check out even more in-depth UConn vs. Southern Miss analysis on FanDuel Research.