Twins vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 2:14 p.m.

The Sunday schedule in MLB includes a matchup between the Minnesota Twins and the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Twins vs Guardians Game Info

• Minnesota Twins (70-78) vs. Cleveland Guardians (75-74)
• Date: Sunday, September 13, 2026
• Time: 2:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and CleGuardians.TV

Twins vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-124) | CLE: (+106)
• Spread: MIN: +1.5 (-215) | CLE: -1.5 (+176)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Twins vs Guardians Probable Starting Pitchers

Probable Pitchers: Joe Ryan (Twins) - 6-9, 4.10 ERA vs Tanner Bibee (Guardians) - 5-15, 4.22 ERA

The probable pitchers are Joe Ryan (6-9) for the Twins and Tanner Bibee (5-15) for the Guardians. Ryan and his team have a record of 13-10-0 against the spread when he starts. Ryan's team is 8-8 this season when he starts and they are the moneyline favorite. The Guardians have a 7-21-0 record against the spread in Bibee's starts. The Guardians are 5-8 in Bibee's 13 starts this season that they were the moneyline underdog.

Twins vs Guardians Moneyline

• Looking at the moneyline for Twins-Guardians, Minnesota is the favorite at -124, and Cleveland is +106 playing on the road.

Twins vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Twins. The Guardians are +176 to cover, while the Twins are -215 to cover as a 1.5-run underdog on the runline.

Twins vs Guardians Over/Under

• The over/under for Twins-Guardians on Sept. 13 is 7.5. The over is -120, and the under is -102.

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Twins vs Guardians Betting Trends

• The Twins have been chosen as favorites in 53 games this year and have walked away with the win 28 times (52.8%) in those games.
• This season Minnesota has come away with a win 13 times in 27 chances when named as a favorite of at least -124 on the moneyline.
• The Twins and their opponents have hit the over in 80 of their 144 games with a total set by oddsmakers this season.
• The Twins have posted a record of 78-66-0 against the spread this season.
• The Guardians are 27-27 in games they were the underdog on the moneyline (winning 50% of those games).
• When it has played as a moneyline underdog with odds of +106 or longer, Cleveland has a 20-18 record (winning 52.6% of its games).
• The Guardians have had an over/under set by bookmakers 141 times, and have combined with opponents to go over the total in 68 of those games (68-73-0).
• The Guardians have gone 66-75-0 ATS this season.

Twins Player Leaders

• Brooks Lee has an OPS of .731, fueled by an OBP of .298 and a team-best slugging percentage of .433 this season. He has a .249 batting average.
• He ranks 76th in batting average, 121st in on-base percentage, and 60th in slugging among all qualifying hitters in the majors.
• Josh Bell has hit 19 homers this season while driving in 86 runs. He's batting .253 this season and slugging .420 with an on-base percentage of .318.
• He is 71st in batting average, 88th in on-base percentage and 73rd in slugging in MLB.
• Kody Clemens leads Minnesota in total hits (116) this season, and 53 of those have gone for extra bases.
• Clemens heads into this game with five games in a row with at least one hit. In his last five games he is hitting .316 with two home runs, two walks and four RBIs.
• Luke Keaschall has 130 hits this season and a team-best OBP of .364.

Guardians Player Leaders

• Chase DeLauter is leading the Guardians with 133 hits. He's batting .291 and slugging .457 with an on-base percentage of .363.
• Including all the qualifying hitters in the majors, he is 12th in batting average, 24th in on-base percentage and 42nd in slugging percentage.
• Steven Kwan paces his team with a .371 on-base percentage, and has a club-high .335 slugging percentage. He has a batting average of .274.
• Including all qualified players, he ranks 31st in batting average, 13th in on-base percentage and 136th in slugging percentage.
• Jose Ramirez has 24 doubles, 11 home runs and 57 walks while hitting .230.
• Brayan Rocchio is hitting .246 with 21 doubles, two triples, 13 home runs and 34 walks.

Twins vs Guardians Head to Head

• 9/12/2026: 4-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/11/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/23/2026: 3-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/22/2026: 10-6 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/21/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

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