White Sox vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 13

Odds updated as of 2:13 p.m.

The Chicago White Sox versus the St. Louis Cardinals is on the MLB schedule for Sunday.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

White Sox vs Cardinals Game Info

• Chicago White Sox (76-72) vs. St. Louis Cardinals (73-76)
• Date: Sunday, September 13, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CHSN

White Sox vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-116) | STL: (-102)
• Spread: CHW: -1.5 (+142) | STL: +1.5 (-172)
• Total: 8.5 -- Over: (-122) | Under: (+100)

White Sox vs Cardinals Probable Starting Pitchers

Probable Pitchers: David Sandlin (White Sox) - 2-1, 6.93 ERA vs Michael McGreevy (Cardinals) - 6-9, 3.92 ERA

The probable pitchers are David Sandlin (2-1) for the White Sox and Michael McGreevy (6-9) for the Cardinals. When Sandlin starts, his team is 2-1-0 against the spread this season. Sandlin's team won his only start as a favorite this season. The Cardinals are 16-12-0 ATS in McGreevy's 28 starts with a set spread. The Cardinals have been the underdog on the moneyline in 20 of McGreevy's starts this season, and they went 10-10 in those matchups.

White Sox vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.1%)

White Sox vs Cardinals Moneyline

• Looking at the moneyline for White Sox-Cardinals, Chicago is the favorite at -116, and St. Louis is -102 playing at home.

White Sox vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the White Sox. The Cardinals are -172 to cover, and the White Sox are +142.

White Sox vs Cardinals Over/Under

• White Sox versus Cardinals on Sept. 13 has an over/under of 8.5 runs, with the odds on the over -122 and the under set at +100.

Bet on Chicago White Sox vs. St. Louis Cardinals on FanDuel today!

White Sox vs Cardinals Betting Trends

• The White Sox have been victorious in 19, or 54.3%, of the 35 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win 16 times in 29 chances when named as a favorite of at least -116 on the moneyline.
• The White Sox's games have gone over the total in 80 of their 145 opportunities.
• The White Sox have an against the spread record of 81-64-0 in 145 games with a line this season.
• The Cardinals have won 46.3% of the games this season they were the moneyline underdog (44-51).
• St. Louis is 38-44 (winning 46.3% of its games) when playing as a moneyline underdog of -102 or longer.
• The Cardinals have combined with opponents to go over the total 67 times this season for a 67-71-7 record against the over/under.
• The Cardinals are 79-66-0 against the spread this season.

White Sox Player Leaders

• Miguel Vargas has 30 doubles, a triple, 30 home runs and 88 walks while batting .247. He has an on-base percentage of .356 and a slugging percentage of .471.
• Among all qualifying hitters, he ranks 81st in batting average, his on-base percentage ranks 35th, and he is 30th in slugging.
• Vargas has recorded a base hit in two straight games. In his last five games he is batting .100 with a walk.
• Chase Meidroth has hit 14 homers this season while driving in 53 runs. He's batting .268 this season and slugging .400 with an on-base percentage of .345.
• Among all qualified hitters, he ranks 47th in batting average, 49th in on-base percentage and 89th in slugging percentage.
• Sam Antonacci leads Chicago with an OBP of .367 this season while batting .269 with 42 walks and 74 runs scored.
• Antonacci has recorded at least one base hit in two straight games. In his last five games he is hitting .294 with an RBI.
• Tristan Peters has been key for Chicago with 113 hits, an OBP of .345 plus a slugging percentage of .462.

Cardinals Player Leaders

• Alec Burleson has put up a slugging percentage of .465, a team-best for the Cardinals. He's batting .282 with an on-base percentage of .349.
• He is 18th in batting average, 45th in on-base percentage and 34th in slugging percentage among all qualified hitters in the big leagues.
• Jordan Walker paces his team with 159 hits and has a club-leading .490 slugging percentage. He has a batting average of .282 with an on-base percentage of .338.
• Including all qualified hitters, he ranks 18th in batting average, 58th in on-base percentage and 21st in slugging percentage.
• Ivan Herrera has an on-base percentage of .359, a team-high for the Cardinals.
• Nathan Church is hitting .251 with 13 doubles, two triples, 10 home runs and 24 walks.

White Sox vs Cardinals Head to Head

• 9/12/2026: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/11/2026: 7-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/19/2025: 8-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/19/2025: 5-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/17/2025: 12-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/5/2024: 5-1 CHW (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/4/2024: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/3/2024: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 7/9/2023: 4-3 STL (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2023: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)

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