NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 1

The NFL Sunday schedule in Week 1 is sure to please. The matchups include the Buffalo Bills squaring off against the Houston Texans at NRG Stadium.

With Sunday upon us in Week 1 of the NFL season, stay on top of the most current betting odds with our preview below.

Jaguars vs. Browns

The 2026 NFL season begins on Sunday, Sept. 13 for the Jacksonville Jaguars (0-0) and the Cleveland Browns (0-0), who take the field for a Week 1 matchup at EverBank Stadium at 1 p.m. ET. The Jaguars finished 13-4 a season ago, while the Browns had a 5-12 record in 2025.

• Game Preview: Cleveland Browns at Jacksonville Jaguars
• Projected Favorite: Jaguars (77.84% win probability)
• Spread: Jacksonville (-8.5)
• Total: 40.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. Cleveland with FanDuel Sportsbook.

Bengals vs. Buccaneers

One of the best pass-catchers in football last season will be on display when Ja'Marr Chase and the Cincinnati Bengals host the Tampa Bay Buccaneers on Sunday, September 13, 2026.

• Game Preview: Tampa Bay Buccaneers at Cincinnati Bengals
• Projected Favorite: Bengals (52.88% win probability)
• Spread: Cincinnati (-3.5)
• Total: 50.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cincinnati vs. Tampa Bay with FanDuel Sportsbook.

Titans vs. Jets

The Tennessee Titans play on Sunday at 1 p.m. ET versus the New York Jets at Nissan Stadium.

• Game Preview: New York Jets at Tennessee Titans
• Projected Favorite: Titans (52.83% win probability)
• Spread: Tennessee (-1.5)
• Total: 38.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. New York with FanDuel Sportsbook.

Lions vs. Saints

The Detroit Lions (0-0) and the New Orleans Saints (0-0) start the 2026 NFL season on Sunday, Sept. 13, with kickoff set for 1 p.m. ET at Ford Field. The Lions are coming off a 9-8 season that saw them miss the playoffs, while the Saints went 6-11 last year and missed the playoffs.

• Game Preview: New Orleans Saints at Detroit Lions
• Projected Favorite: Lions (70.00% win probability)
• Spread: Detroit (-6.5)
• Total: 49.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. New Orleans with FanDuel Sportsbook.

Texans vs. Bills

The 2026 NFL season begins on Sunday, Sept. 13 for the Buffalo Bills (0-0) and the Houston Texans (0-0), who meet for a Week 1 matchup at NRG Stadium at 1 p.m. ET. The Bills start their campaign after they lost in the Divisional round and had a 12-5 record in 2025, while the Texans went 12-5 last year and lost in the Divisional round.

• Game Preview: Buffalo Bills at Houston Texans
• Projected Favorite: Bills (52.23% win probability)
• Spread: Buffalo (-1.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Buffalo with FanDuel Sportsbook.

Colts vs. Ravens

Derrick Henry and the Baltimore Ravens will visit Jonathan Taylor and the Indianapolis Colts on Sunday at 1 p.m. ET, in a matchup featuring two of the best running backs in football last season.

• Game Preview: Baltimore Ravens at Indianapolis Colts
• Projected Favorite: Ravens (57.21% win probability)
• Spread: Baltimore (-3.5)
• Total: 48.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Baltimore with FanDuel Sportsbook.

Steelers vs. Falcons

One of the top pass-catchers in football last season will be featured when Kyle Pitts and the Atlanta Falcons visit the Pittsburgh Steelers on Sunday, September 13, 2026.

• Game Preview: Atlanta Falcons at Pittsburgh Steelers
• Projected Favorite: Steelers (60.95% win probability)
• Spread: Pittsburgh (-6.5)
• Total: 40.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Pittsburgh vs. Atlanta with FanDuel Sportsbook.

Panthers vs. Bears

The Chicago Bears (0-0) visit the Carolina Panthers (0-0) at Bank of America Stadium on Sunday, Sept. 13 at 1 p.m. ET to begin the 2026 NFL season. Last year the Bears lost in the Divisional round after an 11-6 season, while the Panthers finished 8-9 and lost in the Wild Card round.

• Game Preview: Chicago Bears at Carolina Panthers
• Projected Favorite: Bears (55.18% win probability)
• Spread: Chicago (-3)
• Total: 46.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Chicago with FanDuel Sportsbook.

Chargers vs. Cardinals

The 2026 NFL season begins on Sunday, Sept. 13 for the Los Angeles Chargers (0-0) and the Arizona Cardinals (0-0), who meet for a Week 1 matchup at SoFi Stadium at 4:25 p.m. ET. The Chargers start their campaign after they lost in the Wild Card round and had an 11-6 record in 2025, while the Cardinals went 3-14 last year and missed the playoffs.

• Game Preview: Arizona Cardinals at Los Angeles Chargers
• Projected Favorite: Chargers (76.45% win probability)
• Spread: Los Angeles (-8.5)
• Total: 47.5 -- Over: (-102) | Under: (-120)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Los Angeles vs. Arizona with FanDuel Sportsbook.

Raiders vs. Dolphins

One of the best running backs in football last year will be on display when De'Von Achane and the Miami Dolphins visit the Las Vegas Raiders on Sunday, September 13, 2026.

• Game Preview: Miami Dolphins at Las Vegas Raiders
• Projected Favorite: Dolphins (50.71% win probability)
• Spread: Las Vegas (-3)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Las Vegas vs. Miami with FanDuel Sportsbook.

Eagles vs. Commanders

The Washington Commanders will visit the Philadelphia Eagles on Sunday at 4:25 p.m. ET.

• Game Preview: Washington Commanders at Philadelphia Eagles
• Projected Favorite: Eagles (69.94% win probability)
• Spread: Philadelphia (-5.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Washington with FanDuel Sportsbook.

Vikings vs. Packers

At U.S. Bank Stadium on Sunday, the Minnesota Vikings face the Green Bay Packers.

• Game Preview: Green Bay Packers at Minnesota Vikings
• Projected Favorite: Packers (52.76% win probability)
• Spread: Minnesota (-1.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Minnesota vs. Green Bay with FanDuel Sportsbook.

Giants vs. Cowboys

One of the top pass-catchers in football last year will be featured when George Pickens and the Dallas Cowboys visit the New York Giants on Sunday, September 13, 2026.

• Game Preview: Dallas Cowboys at New York Giants
• Projected Favorite: Cowboys (62.78% win probability)
• Spread: Dallas (-3)
• Total: 47.5 -- Over: (-112) | Under: (-108)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on New York vs. Dallas with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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