Tigers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for March 26

Odds updated as of 4:12 p.m.

The Detroit Tigers and the San Diego Padres meet for MLB Opening Day on Thursday.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Padres Game Info

• Detroit Tigers (0-0) vs. San Diego Padres (0-0)
• Date: Thursday, March 26, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and DSN

Tigers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-126) | SD: (+108)
• Spread: DET: -1.5 (+140) | SD: +1.5 (-170)
• Total: 7 -- Over: (-106) | Under: (-114)

Tigers vs Padres Probable Starting Pitchers

Probable Pitchers: Tarik Skubal (Tigers) - 0-0, 0.00 ERA vs Nick Pivetta (Padres) - 0-0, 0.00 ERA

The Tigers will look to Tarik Skubal against the Padres and Nick Pivetta. Skubal and his team were 15-19-0 ATS in his 34 appearances with a spread last season. Skubal and his team had a 21-11 record when he pitched as a favorite last season. Last season in games Pivetta pitched his team finished 18-14-0 against the spread. Pivetta and his team went 7-5 in games he appeared in when they were the underdog on the moneyline a season ago.

Tigers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.1%)

Tigers vs Padres Moneyline

• Detroit is the favorite, -126 on the moneyline, while San Diego is a +108 underdog despite being at home.

Tigers vs Padres Spread

• The Tigers are at the Padres and are favored by 1.5 runs (+140 to cover) on the runline. San Diego is -170 to cover.

Tigers vs Padres Over/Under

• The over/under for the Tigers versus Padres game on March 26 has been set at 7, with -106 odds on the over and -114 odds on the under.

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Tigers vs Padres Betting Trends

• The Tigers came away with 59 wins in the 108 contests they were listed as the favorites last season.
• Last season Detroit came away with a win 51 times in 88 chances when named as a favorite of at least -126 or shorter on the moneyline.
• The Tigers and their opponents hit the over in 80 of their 162 games with a total last season.
• The Padres finished 34-36 in games they were the underdog on the moneyline last season (winning 48.6% of those games).
• San Diego went 22-25 when it played as a moneyline underdog with odds of +108 or longer (46.8%).
• The Padres combined with their opponents to go over the total 70 times last season for a 70-90-3 record against the over/under.

Tigers Player Leaders

• Gleyber Torres collected 136 hits last season and finished with a .358 OBP.
• Riley Greene finished with 155 hits and a slugging percentage of .493.
• Spencer Torkelson ended his last campaign with 135 hits, an OBP of .333, plus a slugging percentage of .456.
• Zach McKinstry slashed .259/.333/.438 and finished with an OPS of .771.

Padres Player Leaders

• Fernando Tatis Jr. had a .368 on-base percentage last season while batting .268.
• Manny Machado registered 169 hits and slugged .460.
• Ramon Laureano had 26 doubles, two triples, 24 home runs and 35 walks while hitting .281 last season.
• Xander Bogaerts hit .263 with 30 doubles, 11 home runs and 48 walks.

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