Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 11:11 a.m.

The MLB slate on Sunday includes the Detroit Tigers facing the Cleveland Guardians.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Tigers vs Guardians Game Info

• Detroit Tigers (33-20) vs. Cleveland Guardians (29-22)
• Date: Sunday, May 25, 2025
• Time: 11:35 a.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: Roku

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-290) | CLE: (+235)
• Spread: DET: -1.5 (-126) | CLE: +1.5 (+104)
• Total: 7 -- Over: (-118) | Under: (-104)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Tarik Skubal (Tigers) - 4-2, 2.87 ERA vs Logan Allen (Guardians) - 2-2, 3.86 ERA

This contest's pitching matchup is set, as the Tigers will send Tarik Skubal (4-2) to the mound, while Logan Allen (2-2) will get the nod for the Guardians. Skubal's team is 5-5-0 against the spread this season in his starts. Skubal's team is 7-2 this season when he starts and they are the moneyline favorite. The Guardians have a 3-5-0 record against the spread in Allen's starts. The Guardians have a 2-3 record in Allen's five starts this season when they were the moneyline underdog.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (67%)

Tigers vs Guardians Moneyline

• The Tigers vs Guardians moneyline has Detroit as a -290 favorite, while Cleveland is a +235 underdog on the road.

Tigers vs Guardians Spread

• The Guardians are +1.5 on the run line against the Tigers. The Guardians are +104 to cover, and the Tigers are -126.

Tigers vs Guardians Over/Under

• A combined run total of 7 has been set for Tigers-Guardians on May 25, with the over at -118 and the under at -104.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have won in 21, or 67.7%, of the 31 contests they have been named as odds-on favorites in this year.
• Detroit has played as a favorite of -290 or more just one time this year and came away with a win in that game.
• The Tigers and their opponents have hit the over in 26 of their 52 games with a total set by oddsmakers this season.
• The Tigers have posted a record of 27-25-0 against the spread this season.
• The Guardians have won 16 of the 30 games they were listed as the moneyline underdog this season (53.3%).
• Cleveland has never played a game this season with moneyline odds of +235 or longer.
• The Guardians have played in 49 games with an over/under set, and have combined with opponents to go over the total 23 times (23-24-2).
• The Guardians have collected a 24-25-0 record against the spread this season (covering 49% of the time).

Tigers Player Leaders

• Spencer Torkelson has 44 hits, which is tops among Detroit hitters this season, while batting .239 with 26 extra-base hits. He has an on-base percentage of .347 and a slugging percentage of .522.
• Among qualifying hitters, he is 108th in batting average, his on-base percentage ranks 55th, and he is 21st in slugging.
• Gleyber Torres leads Detroit with an OBP of .374 this season while batting .281 with 20 walks and 21 runs scored. He's slugging .432.
• He is 38th in batting average, 28th in on-base percentage and 68th in slugging among qualified batters.
• Riley Greene has hit 12 homers with a team-high .508 SLG this season.
• Kerry Carpenter has been key for Detroit with 50 hits, an OBP of .314 plus a slugging percentage of .506.
• Carpenter has safely hit in three straight games. In his last five games he is hitting .250 with two doubles, a home run, two walks and an RBI.

Guardians Player Leaders

• Jose Ramirez leads the Guardians with 57 hits. He's batting .308 and slugging .519 with an on-base percentage of .365.
• Including all qualified hitters in the majors, his batting average places him 13th, his on-base percentage ranks 36th, and he is 23rd in slugging.
• Ramirez enters this matchup on a 17-game hitting streak. During his last 10 games he is batting .372 with two doubles, a triple, three home runs, two walks and eight RBIs.
• Steven Kwan's .378 OBP and .438 slugging percentage both lead his team. He has a batting average of .320.
• Including all qualifying players, his batting average places him sixth, his on-base percentage is 25th, and he is 63rd in slugging.
• Carlos Santana has five doubles, six home runs and 27 walks while hitting .235.
• Kyle Manzardo is hitting .220 with six doubles, two triples, 10 home runs and 21 walks.

Tigers vs Guardians Head to Head

• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/12/2024: 7-3 CLE (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/10/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/9/2024: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/7/2024: 3-0 DET (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/5/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/30/2024: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/29/2024: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!