Tigers vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 6:12 p.m.

The MLB's Tuesday slate includes the Detroit Tigers facing the Milwaukee Brewers.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Brewers Game Info

• Detroit Tigers (12-11) vs. Milwaukee Brewers (12-9)
• Date: Tuesday, April 21, 2026
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and Brewers.TV

Tigers vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-112) | MIL: (-104)
• Spread: DET: +1.5 (-194) | MIL: -1.5 (+160)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Tigers vs Brewers Probable Starting Pitchers

Probable Pitchers: Keider Montero (Tigers) - 1-1, 3.31 ERA vs Kyle Harrison (Brewers) - 1-1, 3.07 ERA

This contest's pitching matchup is set, as the Tigers will send Keider Montero (1-1) to the mound, while Kyle Harrison (1-1) will take the ball for the Brewers. Montero's team is 2-1-0 against the spread this season in his starts. Montero's team is 1-1 this season when he starts and they're favored on the moneyline. The Brewers have a 1-2-0 ATS record in Harrison's three starts with a set spread. The Brewers were named the moneyline underdog for one Harrison start this season -- they won.

Tigers vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (51.5%)

Tigers vs Brewers Moneyline

• Milwaukee is the underdog, -104 on the moneyline, while Detroit is a -112 favorite at home.

Tigers vs Brewers Spread

• The Brewers are 1.5-run favorites against the spread for this matchup with the Tigers. The Brewers are +160 to cover, while the Tigers are -194 to cover as a 1.5-run underdog on the runline.

Tigers vs Brewers Over/Under

• The Tigers-Brewers contest on April 21 has been given an over/under of 8.5 runs. The over is set at -108 and the under at -112.

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Tigers vs Brewers Betting Trends

• The Tigers have been chosen as favorites in 14 games this year and have walked away with the win nine times (64.3%) in those games.
• This season Detroit has come away with a win nine times in 14 chances when named as a favorite of at least -112 on the moneyline.
• The Tigers' games have gone over the total in 10 of their 23 opportunities.
• The Tigers have posted a record of 12-11-0 against the spread this season.
• The Brewers have gone 3-4 in games they were listed as the moneyline underdog (winning 42.9% of those games).
• Milwaukee has gone 2-2 in games it has played as a moneyline underdog with odds of -104 or longer (50%).
• The Brewers have played in 21 games with a set over/under, and have combined with opponents to go over the total 12 times (12-9-0).
• The Brewers have collected a 13-8-0 record ATS this season.

Tigers Player Leaders

• Kevin McGonigle leads Detroit with an OBP of .411, plus a team-best slugging percentage of .488. He's batting .317 on the season.
• Among all qualified hitters in the majors, he is 13th in batting average, 13th in on-base percentage, and 41st in slugging.
• McGonigle hopes to build on a five-game hitting streak in this matchup. In his last five games he is hitting .333 with a double, a triple, two walks and an RBI.
• Dillon Dingler leads Detroit with 19 hits. He is batting .284 this season and has nine extra-base hits. He's also slugging .567 with an on-base percentage of .368.
• Among qualifiers, he ranks 40th in batting average, 44th in on-base percentage and 15th in slugging percentage.
• Riley Greene has collected 21 base hits, an OBP of .372 and a slugging percentage of .388 this season.
• Greene takes a two-game hitting streak into this game. During his last five outings he is hitting .429 with three doubles, five walks and four RBIs.
• Gleyber Torres has been key for Detroit with 20 hits, an OBP of .356 plus a slugging percentage of .298.
• Torres has safely hit in three straight games. During his last five outings he is batting .250 with a double, four walks and three RBIs.

Brewers Player Leaders

• Brice Turang has accumulated 21 hits with a .571 slugging percentage, both team-high statistics for the Brewers. He's batting .300 and with an on-base percentage of .437.
• Including all qualifying hitters, he is 23rd in batting average, while his on-base percentage is fifth and he is 14th in slugging.
• William Contreras is slugging .452 to lead his team. He has a batting average of .288 with an on-base percentage of .381.
• He ranks 35th in batting average, 28th in on-base percentage and 64th in slugging percentage in the majors.
• Jake Bauers is hitting .224 with a double, five home runs and seven walks.
• Gary Sanchez has a double, five home runs and 13 walks while hitting .238.

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