South Carolina vs Vanderbilt Prediction, Odds, Picks, Best Bets for Week 3 2025

The South Carolina Gamecocks versus the Vanderbilt Commodores is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

South Carolina vs Vanderbilt Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: South Carolina: (-152) | Vanderbilt: (+126)
• Spread: South Carolina: -3.5 (-105) | Vanderbilt: +3.5 (-115)
• Total: 48.5 -- Over: (-110) | Under: (-110)

South Carolina vs Vanderbilt Betting Trends

• South Carolina has posted one win against the spread this year.
• South Carolina has won once ATS (1-1) as a 3.5-point or higher favorite this year.
• Vanderbilt has won twice against the spread this year.
• Vanderbilt has had one game (of two) go over the total this year.

South Carolina vs Vanderbilt Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Gamecocks win (71.6%)

South Carolina vs Vanderbilt Point Spread

Vanderbilt is an underdog by 3.5 points versus South Carolina. Vanderbilt is -115 to cover the spread, and South Carolina is -105.

South Carolina vs Vanderbilt Over/Under

A total of 48.5 points has been set for the South Carolina-Vanderbilt game on Sept. 13, with the over available at -110 and the under at -110.

South Carolina vs Vanderbilt Moneyline

The moneyline numbers for South Carolina vs. Vanderbilt reveal South Carolina as the favorite (-152) and Vanderbilt as the underdog (+126).

South Carolina vs. Vanderbilt Points Insights

South Carolina vs. Vanderbilt Game Info

• Game day: Saturday, September 13, 2025
• Game time: 7:45 p.m. ET
• TV channel: SEC Network
• Location: Columbia, South Carolina
• Stadium: Williams-Brice Stadium

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Check out even more in-depth South Carolina vs. Vanderbilt analysis on FanDuel Research.