Royals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 4:12 a.m.

The Kansas City Royals will face the San Diego Padres in MLB action on Sunday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Royals vs Padres Game Info

• Kansas City Royals (38-39) vs. San Diego Padres (41-35)
• Date: Sunday, June 22, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSKC

Royals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-112) | SD: (-104)
• Spread: KC: -1.5 (+146) | SD: +1.5 (-178)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Royals vs Padres Probable Starting Pitchers

Probable Pitchers: Seth Lugo (Royals) - 4-5, 3.05 ERA vs Randy Vasquez (Padres) - 3-4, 3.70 ERA

This contest's pitching matchup is set, as the Royals will send Seth Lugo (4-5) to the mound, while Randy Vasquez (3-4) will get the nod for the Padres. Lugo and his team are 6-7-0 ATS this season when he starts. Lugo's team has won 50% of his starts when they are favored on the moneyline (2-2). The Padres have gone 7-7-0 against the spread when Vasquez starts. The Padres have a 3-7 record in Vasquez's 10 starts this season when they were the moneyline underdog.

Royals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.4%)

Royals vs Padres Moneyline

• Looking at the moneyline for Padres-Royals, San Diego is the underdog at -104, and Kansas City is -112 playing on the road.

Royals vs Padres Spread

• The Padres are +1.5 on the spread (-178 to cover), and Kansas City is +146 to cover the runline.

Royals vs Padres Over/Under

• A total of 8.5 runs has been set for the Royals-Padres contest on June 22, with the over available at -100 and the under at -122.

Bet on Kansas City Royals vs. San Diego Padres on FanDuel today!

Royals vs Padres Betting Trends

• The Royals have been victorious in 15, or 48.4%, of the 31 contests they have been chosen as favorites in this season.
• Kansas City has a record of 15-16 in contests when oddsmakers favor them by -112 or more on the moneyline.
• The Royals and their opponents have hit the over in 30 of their 77 games with a total set by oddsmakers this season.
• The Royals are 41-36-0 against the spread in their 77 games with a line set by sportsbooks this season.
• The Padres have been the moneyline underdog 36 total times this season. They've gone 16-20 in those games.
• San Diego has a 16-19 record (winning 45.7% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Padres have played in 75 games with a set over/under, and have combined with their opponents to go over the total 32 times (32-41-2).
• The Padres have put together a 41-34-0 record against the spread this season (covering 54.7% of the time).

Royals Player Leaders

• Bobby Witt Jr. has 26 doubles, three triples, 10 home runs and 26 walks while batting .283. He has an on-base percentage of .341 and a slugging percentage of .490.
• Among qualifying hitters in the majors, he is 30th in batting average, 60th in on-base percentage, and 27th in slugging.
• Witt will look for his seventh straight game with a hit in this contest. During his last 10 outings he is hitting .231 with four doubles, two home runs, three walks and three RBIs.
• Maikel Garcia leads Kansas City in OBP (.374), slugging percentage (.493) and total hits (87) this season. He's batting .315.
• Among qualifying hitters, his batting average places him eighth, his on-base percentage 23rd, and his slugging percentage 25th.
• Vinnie Pasquantino has collected 78 base hits, an OBP of .328 and a slugging percentage of .411 this season.
• Jonathan India has four home runs, 22 RBI and a batting average of .242 this season.

Padres Player Leaders

• Manny Machado has put up a team-best OBP (.373) and slugging percentage (.503), while pacing the Padres in hits (89, while batting .309).
• Including all qualifying hitters in MLB, he ranks 11th in batting average, 24th in on-base percentage and 21st in slugging percentage.
• Fernando Tatis Jr. is batting .268 with 11 doubles, a triple, 14 home runs and 36 walks. He's slugging .461 with an on-base percentage of .357.
• Including all qualified players, he is 54th in batting average, 35th in on-base percentage and 52nd in slugging percentage.
• Luis Arraez has 16 doubles, four triples, three home runs and 13 walks while hitting .280.
• Gavin Sheets is hitting .265 with 11 doubles, a triple, 12 home runs and 20 walks.

Royals vs Padres Head to Head

• 6/21/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/20/2025: 6-5 KC (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/2/2024: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/1/2024: 7-3 SD (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/31/2024: 11-8 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2023: 4-3 KC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 5/16/2023: 5-4 KC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/15/2023: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/28/2022: 15-7 KC (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 8/27/2022: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)

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