Royals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 4:15 p.m.

The Sunday slate in MLB includes a matchup between the San Diego Padres and the Kansas City Royals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Royals Game Info

• San Diego Padres (41-35) vs. Kansas City Royals (38-39)
• Date: Sunday, June 22, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSKC

Padres vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-118) | KC: (-100)
• Spread: SD: +1.5 (-200) | KC: -1.5 (+164)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Padres vs Royals Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 3-4, 3.70 ERA vs Seth Lugo (Royals) - 4-5, 3.05 ERA

The Padres will give the nod to Randy Vasquez (3-4) against the Royals and Seth Lugo (4-5). When Vasquez starts, his team is 7-7-0 against the spread this season. Vasquez and his team have won each of the four games he's started as the moneyline favorite. The Royals have a 6-7-0 record against the spread in Lugo's starts. The Royals are 4-5 in Lugo's nine starts this season that they were the moneyline underdog.

Padres vs Royals Moneyline

• Kansas City is the underdog, -100 on the moneyline, while San Diego is a -118 favorite at home.

Padres vs Royals Spread

• The Royals are 1.5-run favorites against the spread for this matchup with the Padres. The Royals are +164 to cover, while the Padres are -200 to cover as a 1.5-run underdog on the runline.

Padres vs Royals Over/Under

• A total of 8.5 runs has been set for the Padres-Royals game on June 22, with the over available at -115 and the under at -105.

Bet on San Diego Padres vs. Kansas City Royals on FanDuel today!

Padres vs Royals Betting Trends

• The Padres have come away with 22 wins in the 36 contests they have been listed as the favorites in this season.
• This season San Diego has come away with a win 21 times in 33 chances when named as a favorite of at least -118 on the moneyline.
• The Padres and their opponents have hit the over in 32 of their 75 games with a total set by oddsmakers this season.
• In 75 games with a line this season, the Padres have a mark of 41-34-0 against the spread.
• The Royals have won 23 of the 46 games they were the underdog on the moneyline this season (50%).
• In games it has played as a moneyline underdog with odds of -100 or longer, Kansas City has gone 15-21 (41.7%).
• The Royals have combined with opponents to go over the total 30 times this season for a 30-45-2 record against the over/under.
• The Royals have a 41-36-0 record against the spread this season (covering 53.2% of the time).

Padres Player Leaders

• Manny Machado leads San Diego with 89 hits and an OBP of .373, plus a team-best slugging percentage of .503. He's batting .309.
• Among qualifying batters in baseball, he is 11th in batting average, 24th in on-base percentage, and 21st in slugging.
• Fernando Tatis Jr. has 11 doubles, a triple, 14 home runs and 36 walks. He's batting .268 and slugging .461 with an on-base percentage of .357.
• His batting average ranks 55th among qualified players, his on-base percentage 35th, and his slugging percentage 51st.
• Luis Arraez has collected 80 base hits, an OBP of .310 and a slugging percentage of .395 this season.
• Arraez heads into this game with eight games in a row with at least one hit. During his last 10 games he is batting .273 with a double, a triple, a walk and four RBIs.
• Gavin Sheets has been key for San Diego with 65 hits, an OBP of .322 plus a slugging percentage of .465.
• Sheets enters this matchup on a 12-game hitting streak. During his last 10 games he is batting .351 with three doubles, a home run, four walks and seven RBIs.

Royals Player Leaders

• Bobby Witt Jr. is hitting .283 with 26 doubles, three triples, 10 home runs and 26 walks. He's slugging .490 with an on-base percentage of .341.
• Including all qualifying hitters in the big leagues, he ranks 30th in batting average, 61st in on-base percentage and 27th in slugging percentage.
• Witt heads into this matchup on a six-game hitting streak. During his last 10 outings he is hitting .231 with four doubles, two home runs, three walks and three RBIs.
• Maikel Garcia paces his team with 87 hits and a .374 OBP, with a team-high .493 slugging percentage. He has a batting average of .315.
• He is eighth in batting average, 23rd in on-base percentage and 25th in slugging percentage in the big leagues.
• Vinnie Pasquantino has seven doubles, a triple, 11 home runs and 23 walks while hitting .267.
• Jonathan India is hitting .242 with 13 doubles, four home runs and 28 walks.

Padres vs Royals Head to Head

• 6/21/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/20/2025: 6-5 KC (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/2/2024: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/1/2024: 7-3 SD (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/31/2024: 11-8 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2023: 4-3 KC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 5/16/2023: 5-4 KC (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/15/2023: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/28/2022: 15-7 KC (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 8/27/2022: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)

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