Reds vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for July 28

Odds updated as of 4:12 p.m.

Tuesday's slate in the MLB includes a matchup between the Cincinnati Reds and the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Reds vs Guardians Game Info

• Cincinnati Reds (49-55) vs. Cleveland Guardians (54-53)
• Date: Tuesday, July 28, 2026
• Time: 7:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and CleGuardians.TV

Reds vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-162) | CLE: (+136)
• Spread: CIN: -1.5 (+120) | CLE: +1.5 (-144)
• Total: 9 -- Over: (-110) | Under: (-110)

Reds vs Guardians Probable Starting Pitchers

Probable Pitchers: TBA (Reds) vs Gavin Williams (Guardians) - 10-5, 0.00 ERA

The Guardians will hand the ball to Williams (10-5, 3.06), while the Reds' starter for this game has not been determined. The Guardians are 10-10-0 against the spread when Williams starts. The Guardians have a 3-2 record in Williams' five starts this season when they were the moneyline underdog.

Reds vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.5%)

Reds vs Guardians Moneyline

• Cincinnati is the favorite, -162 on the moneyline, while Cleveland is a +136 underdog on the road.

Reds vs Guardians Spread

• The Guardians are +1.5 on the spread (-144 to cover), and Cincinnati is +120 to cover the runline.

Reds vs Guardians Over/Under

• The Reds-Guardians game on July 28 has been given an over/under of 9 runs. The over is set at -110 and the under at -110.

Bet on Cincinnati Reds vs. Cleveland Guardians on FanDuel today!

Reds vs Guardians Betting Trends

• The Reds have been favorites in 31 games this season and have come away with the win 16 times (51.6%) in those contests.
• Cincinnati has a record of 4-2 in contests when oddsmakers favor them by -162 or more on the moneyline.
• The Reds' games have gone over the total in 55 of their 102 opportunities.
• The Reds have an against the spread mark of 56-46-0 in 102 games with a line this season.
• The Guardians have been the underdog on the moneyline 47 total times this season. They've gone 24-23 in those games.
• Cleveland is 6-4 (winning 60% of its games) when it has played as a moneyline underdog of +136 or longer.
• The Guardians have combined with opponents to hit the over on the total 48 times this season for a 48-53-0 record against the over/under.
• The Guardians have a 49-52-0 record ATS this season (covering 48.5% of the time).

Reds Player Leaders

• Sal Stewart leads Cincinnati in slugging percentage (.470) thanks to 44 extra-base hits. He has a .253 batting average and an on-base percentage of .329.
• Among qualifying hitters in baseball, he ranks 78th in batting average, 78th in on-base percentage, and 38th in slugging.
• Stewart hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .294 with a home run and six RBIs.
• Elly De La Cruz leads the Reds in OBP (.354) and total hits (94) this season. He's batting .278 while slugging .506.
• Among qualifying hitters, his batting average places him 35th, his on-base percentage 39th, and his slugging percentage 17th.
• De La Cruz brings a three-game streak with at least one hit into this one. During his last five outings he is hitting .263 with two home runs, four walks and two RBIs.
• JJ Bleday has 64 hits this season and has a slash line of .234/.343/.469.
• Nathaniel Lowe has been key for Cincinnati with 57 hits, an OBP of .333 plus a slugging percentage of .475.
• Lowe has safely hit in two straight games. In his last five games he is batting .304 with two home runs and six RBIs.

Guardians Player Leaders

• Chase DeLauter has put up an on-base percentage of .352 and has 94 hits, both team-high figures for the Guardians. He's batting .282 and slugging .447.
• He ranks 25th in batting average, 43rd in on-base percentage and 57th in slugging percentage among all qualifying hitters in the majors.
• Brayan Rocchio is slugging .398 to pace his team. He has a batting average of .268 with an on-base percentage of .328.
• Including all qualifying players, his batting average places him 51st, his on-base percentage is 80th, and he is 102nd in slugging.
• Jose Ramirez is batting .236 with 18 doubles, 10 home runs and 43 walks.
• Steven Kwan is hitting .248 with 13 doubles, two triples, a home run and 51 walks.

Reds vs Guardians Head to Head

• 5/17/2026: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/16/2026: 7-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/15/2026: 7-6 CIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/11/2025: 11-2 CLE (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/10/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 7-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/18/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!