Reds vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for July 28

Odds updated as of 7:12 p.m.

MLB action on Tuesday includes the Cincinnati Reds playing the Cleveland Guardians.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Reds vs Guardians Game Info

• Cincinnati Reds (49-56) vs. Cleveland Guardians (55-53)
• Date: Tuesday, July 28, 2026
• Time: 7:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and CleGuardians.TV

Reds vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-162) | CLE: (+136)
• Spread: CIN: -1.5 (+120) | CLE: +1.5 (-144)
• Total: 9 -- Over: (-110) | Under: (-110)

Reds vs Guardians Probable Starting Pitchers

Probable Pitchers: Caleb Ferguson (Reds) - 1-0, 3.86 ERA vs Gavin Williams (Guardians) - 10-5, 3.78 ERA

This contest's pitching matchup is set, as the Reds will send Caleb Ferguson (1-0) to the mound, while Gavin Williams (10-5) will get the nod for the Guardians. Ferguson did not pitch in a game with a spread last season. Ferguson did not pitch as the moneyline favorite in any games last season. The Guardians have a 10-10-0 ATS record in Williams' 20 starts that had a set spread. The Guardians have been the underdog on the moneyline in five of Williams' starts this season, and they went 3-2 in those games.

Reds vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (52.8%)

Reds vs Guardians Moneyline

• Looking at the moneyline for Reds-Guardians, Cincinnati is the favorite at -162, and Cleveland is +136 playing on the road.

Reds vs Guardians Spread

• The Guardians are +1.5 on the spread (-144 to cover), and Cincinnati is +120 to cover the runline.

Reds vs Guardians Over/Under

• A combined run total of 9 has been set for Reds-Guardians on July 28, with the over at -110 and the under at -110.

Bet on Cincinnati Reds vs. Cleveland Guardians on FanDuel today!

Reds vs Guardians Betting Trends

• The Reds have come away with 16 wins in the 32 contests they have been listed as the favorites in this season.
• This season Cincinnati has been victorious four times in seven chances when named as a favorite of at least -162 on the moneyline.
• The Reds' games have gone over the total in 56 of their 103 opportunities.
• The Reds have posted a record of 56-47-0 against the spread this season.
• The Guardians have been the underdog on the moneyline 48 total times this season. They've finished 25-23 in those games.
• In games it has played as a moneyline underdog with odds of +136 or longer, Cleveland has gone 6-4 (60%).
• The Guardians have combined with opponents to go over the total 49 times this season for a 49-53-0 record against the over/under.
• The Guardians have collected a 50-52-0 record ATS this season.

Reds Player Leaders

• Sal Stewart leads Cincinnati with a slugging percentage of .479, fueled by 45 extra-base hits. He has a .256 batting average and an on-base percentage of .334.
• He is 72nd in batting average, 71st in on-base percentage, and 35th in slugging among qualifying hitters in baseball.
• Stewart hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .412 with two home runs, two walks and eight RBIs.
• Elly De La Cruz has 96 hits and an OBP of .355, both of which lead the Reds this season. He's batting .280 and slugging .504.
• Among all qualifying hitters, he is 31st in batting average, 39th in on-base percentage and 17th in slugging percentage.
• De La Cruz has picked up at least one hit in four straight games. During his last five outings he is hitting .286 with a home run, three walks and an RBI.
• JJ Bleday has 64 hits this season and has a slash line of .230/.337/.460.
• Nathaniel Lowe has been key for Cincinnati with 59 hits, an OBP of .336 plus a slugging percentage of .480.
• Lowe takes a three-game hitting streak into this matchup. In his last five games he is hitting .364 with a double, a home run and three RBIs.

Guardians Player Leaders

• Chase DeLauter has racked up 95 hits with a .351 on-base percentage, leading the Guardians in both categories. He's batting .283 and slugging .446.
• Including all the qualifying hitters in the majors, his batting average ranks 22nd, his on-base percentage ranks 44th, and he is 57th in slugging.
• Jose Ramirez is batting .239 with 18 doubles, 10 home runs and 43 walks. He's slugging .405 with an on-base percentage of .336.
• Including all qualified hitters, he ranks 109th in batting average, 66th in on-base percentage and 92nd in slugging percentage.
• Brayan Rocchio has put up a team-best .397 slugging percentage.
• Steven Kwan is batting .247 with 13 doubles, two triples, a home run and 51 walks.

Reds vs Guardians Head to Head

• 7/28/2026: 6-5 CLE (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/17/2026: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/16/2026: 7-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/15/2026: 7-6 CIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/11/2025: 11-2 CLE (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/10/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 7-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/18/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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