Red Sox vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 4

Odds updated as of 11:21 p.m.

Saturday's slate in the MLB includes a matchup between the Boston Red Sox and the San Diego Padres.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Padres Game Info

• Boston Red Sox (2-5) vs. San Diego Padres (2-5)
• Date: Saturday, April 4, 2026
• Time: 4:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and Padres.TV

Red Sox vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-136) | SD: (+116)
• Spread: BOS: -1.5 (+155) | SD: +1.5 (-188)
• Total: 8 -- Over: (-120) | Under: (-102)

Red Sox vs Padres Probable Starting Pitchers

Probable Pitchers: Connelly Early (Red Sox) - 0-0, 1.69 ERA vs Randy Vasquez (Padres) - 1-0, 0.00 ERA

The Red Sox will look to Connelly Early against the Padres and Randy Vasquez (1-0). Early and his team failed to cover the spread in his only opportunity this season as a starter. Early's team lost his only start as a favorite this season. Vasquez has started only one game with a set spread, which the Padres covered. The Padres have not been a moneyline underdog when Vasquez starts this season.

Red Sox vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (54.8%)

Red Sox vs Padres Moneyline

• Boston is a -136 favorite on the moneyline, while San Diego is a +116 underdog on the road.

Red Sox vs Padres Spread

• The Red Sox are favored by 1.5 runs at home versus the Padres. The Red Sox are +155 to cover the spread, while the Padres are -188.

Red Sox vs Padres Over/Under

• An over/under of 8 has been set for Red Sox-Padres on April 4, with the over being -120 and the under -102.

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Red Sox vs Padres Betting Trends

• The Red Sox have been victorious in two of the six contests they have been chosen as favorites in this season.
• This season Boston has been victorious one time in three chances when named as a favorite of at least -136 on the moneyline.
• The Red Sox and their opponents have gone over in four of their seven games with a total set by sportsbooks this season.
• The Red Sox are 2-5-0 against the spread in their seven games with a line set by sportsbooks this season.
• The Padres have yet to win a game they played as the moneyline underdog this season, going 0-1.
• San Diego has played as a moneyline underdog of +116 or longer in just one game this season, which it lost.
• The Padres have had an over/under set by bookmakers seven times, and have combined with opponents to go over the total in two of those games (2-4-1).
• The Padres have collected a 3-4-0 record ATS this season (covering 42.9% of the time).

Red Sox Player Leaders

• Wilyer Abreu has 11 hits and an OBP of .393 to go with a slugging percentage of .821. All three of those stats are tops among Boston hitters this season. He has a .393 batting average, as well.
• Among qualified batters in the majors, he ranks 12th in batting average, 45th in on-base percentage, and eighth in slugging.
• Abreu has hit safely in two games in a row. In his last five games he is hitting .421 with two doubles, two home runs and four RBIs.
• Marcelo Mayer has three doubles, a home run and two walks. He's batting .294 and slugging .647 with an on-base percentage of .368.
• Jarren Duran is batting .182 with a .227 slugging percentage and two RBI this year.
• Duran has logged a hit or more in two straight games. In his last five games he is hitting .118 with a double, four walks and an RBI.
• Willson Contreras has been key for Boston with four hits, an OBP of .367 plus a slugging percentage of .304.
• Contreras has safely hit in three games in a row. During his last five outings he is batting .235 with a home run, three walks and two RBIs.

Padres Player Leaders

• Ramon Laureano has accumulated a team-high slugging percentage (.636) while pacing the Padres in hits (seven). He's batting .318 and with an on-base percentage of .348.
• Including all the qualified hitters in MLB, his batting average puts him 45th, his on-base percentage ranks 82nd, and he is 22nd in slugging.
• Jackson Merrill is hitting .185 with a double, a home run and two walks. He's slugging .333 with an on-base percentage of .241.
• Including all qualifying hitters, he is 140th in batting average, 159th in on-base percentage and 119th in slugging percentage.
• Fernando Tatis Jr. is hitting .200 with a double and four walks.
• Manny Machado paces his team with a .393 OBP.

Red Sox vs Padres Head to Head

• 4/3/2026: 5-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/10/2025: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/9/2025: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/8/2025: 10-2 BOS (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/30/2024: 4-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 10, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/29/2024: 11-1 SD (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/28/2024: 9-2 SD (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/21/2023: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/20/2023: 4-2 BOS (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/19/2023: 6-1 BOS (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)

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