Red Sox vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:11 p.m.

In MLB action on Tuesday, the Boston Red Sox take on the Seattle Mariners.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Red Sox vs Mariners Game Info

• Boston Red Sox (13-11) vs. Seattle Mariners (12-10)
• Date: Tuesday, April 22, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and ROOT Sports NW

Red Sox vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-122) | SEA: (+104)
• Spread: BOS: -1.5 (+155) | SEA: +1.5 (-188)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Red Sox vs Mariners Probable Starting Pitchers

Probable Pitchers: Brayan Bello (Red Sox) - 0-0, 0.00 ERA vs Bryce Miller (Mariners) - 1-2, 3.43 ERA

The probable starters are Brayan Bello for the Red Sox and Bryce Miller (1-2) for the Mariners. In 29 games he pitched with a spread last season, Bello and his team finished with a 15-14-0 record ATS. Bello and his team were 9-5 when he pitched and they were the moneyline favorite. The Mariners have gone 2-2-0 ATS in Miller's four starts that had a set spread. The Mariners were named the moneyline underdog for two Miller starts this season -- they split the games.

Red Sox vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (52%)

Red Sox vs Mariners Moneyline

• Seattle is the underdog, +104 on the moneyline, while Boston is a -122 favorite at home.

Red Sox vs Mariners Spread

• The Mariners are at +1.5 on the runline against the Red Sox. The Mariners are -188 to cover the spread, and the Red Sox are +155.

Red Sox vs Mariners Over/Under

• Red Sox versus Mariners, on April 22, has an over/under of 9.5, with the over being -100 and the under -122.

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Red Sox vs Mariners Betting Trends

• The Red Sox have been chosen as favorites in 17 games this year and have walked away with the win 10 times (58.8%) in those games.
• This season Boston has been victorious eight times in 14 chances when named as a favorite of at least -122 on the moneyline.
• The Red Sox and their opponents have gone over the total this season in nine of their 24 opportunities.
• The Red Sox have posted a record of 12-12-0 against the spread this season.
• The Mariners have put together a 4-4 record in games they were listed as the moneyline underdog (winning 50% of those games).
• Seattle has a 4-1 record (winning 80% of its games) when playing as a moneyline underdog of +104 or longer.
• The Mariners have combined with opponents to hit the over on the total 10 times this season for a 10-10-2 record against the over/under.
• The Mariners have gone 11-11-0 against the spread this season.

Red Sox Player Leaders

• Alexander David Bregman is hitting .297 with seven doubles, four home runs and nine walks. He has an on-base percentage of .375 and a slugging percentage of .505.
• Among qualifying batters, he is 34th in batting average, his on-base percentage ranks 34th, and he is 34th in slugging.
• Bregman will look for his third straight game with a hit in this contest. In his last five games he is batting .389 with a double, two home runs, five walks and four RBI.
• Wilyer Abreu is hitting .274 with five doubles, four home runs and 15 walks, while slugging .507 with an on-base percentage of .398.
• He is 61st in batting average, 19th in on-base percentage and 32nd in slugging among qualified batters.
• Trevor Story has a team-high 30 hits to go with a slugging percentage of .528.
• Story enters this matchup with three games in a row with at least one hit. During his last five outings he is batting .450 with two home runs, a walk and seven RBI.
• Kristian Campbell leads Boston with an OBP of .418 this season while batting .316 with 14 walks and 11 runs scored.
• Campbell heads into this matchup on a three-game hitting streak. In his last five games he is hitting .278 with a double, four walks and two RBI.

Mariners Player Leaders

• Cal Raleigh has accumulated a team-best slugging percentage (.605) and paces the Mariners in hits (21). He's batting .244 and with an on-base percentage of .343.
• Including all the qualifying hitters in the big leagues, he is 82nd in batting average, 66th in on-base percentage and 11th in slugging percentage.
• Raleigh heads into this matchup on a five-game hitting streak. During his last five outings he is batting .364 with a double, four home runs, four walks and eight RBI.
• Randy Arozarena is hitting .200 with six doubles, four home runs and 16 walks. He's slugging .425 with an on-base percentage of .354.
• He is currently 135th in batting average, 54th in on-base percentage and 74th in slugging percentage among all qualifying hitters.
• Dylan Moore is batting .316 with a double, five home runs and five walks.
• Julio Rodriguez has two doubles, two triples, three home runs and 12 walks while hitting .188.

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