Rays vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 6:15 p.m.

In MLB action on Tuesday, the Cincinnati Reds face the Tampa Bay Rays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Reds vs Rays Game Info

• Cincinnati Reds (15-8) vs. Tampa Bay Rays (12-10)
• Date: Tuesday, April 21, 2026
• Time: 6:40 p.m. ET
• Venue: Tropicana Field -- St. Petersburg, Florida
• Coverage: Rays.TV and Reds.TV

Reds vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-116) | TB: (-102)
• Spread: CIN: -1.5 (+150) | TB: +1.5 (-182)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Reds vs Rays Probable Starting Pitchers

Probable Pitchers: Chase Burns (Reds) - 1-1, 2.42 ERA vs Steven Matz (Rays) - 3-0, 3.80 ERA

This contest's pitching matchup is set, as the Reds will send Chase Burns (1-1) to the mound, while Steven Matz (3-0) will get the nod for the Rays. Burns' team is 1-3-0 against the spread this season in his starts. Burns' team is 1-2 this season when he starts and they are the moneyline favorite. The Rays covered all of Matz's four starts with a set spread. The Rays were the moneyline underdog for one Matz start this season -- they won.

Reds vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (53.3%)

Reds vs Rays Moneyline

• Looking at the moneyline for Reds-Rays, Cincinnati is the favorite at -116, and Tampa Bay is -102 playing at home.

Reds vs Rays Spread

• The Rays are +1.5 on the spread (-182 to cover), and Cincinnati is +150 to cover the runline.

Reds vs Rays Over/Under

• The over/under for Reds-Rays on April 21 is 7.5. The over is -115, and the under is -105.

Bet on Cincinnati Reds vs. Tampa Bay Rays on FanDuel today!

Reds vs Rays Betting Trends

• The Reds have been chosen as favorites in five games this year and have walked away with the win three times (60%) in those games.
• This season Cincinnati has been victorious two times in four chances when named as a favorite of at least -116 on the moneyline.
• The Reds' games have gone over the total in 12 of their 23 opportunities.
• The Reds are 14-9-0 against the spread in their 23 games with a line set by sportsbooks this season.
• The Rays have won six of the 11 games they were the underdog on the moneyline this season (54.5%).
• Tampa Bay is 4-3 (winning 57.1% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Rays have played in 22 games with a set over/under, and have combined with their opponents to go over the total 15 times (15-7-0).
• The Rays have a 12-10-0 record against the spread this season (covering 54.5% of the time).

Reds Player Leaders

• Sal Stewart leads Cincinnati in OBP (.388), slugging percentage (.639) and total hits (24) this season. He has a .289 batting average.
• He is 34th in batting average, 22nd in on-base percentage, and third in slugging among all qualifying hitters in the majors.
• Elly De La Cruz leads Cincinnati in slugging percentage (.511) thanks to 11 extra-base hits. He's batting .261 with an on-base percentage of .333.
• He ranks 70th in batting average, 83rd in on-base percentage and 31st in slugging among qualifying hitters.
• De La Cruz has picked up a hit in four games in a row. During his last five outings he is hitting .190 with two doubles, a walk and two RBIs.
• Eugenio Suarez has 21 hits this season and has a slash line of .256/.330/.402.
• Matt McLain has no home runs, but three RBI and a batting average of .188 this season.
• McLain has safely hit in two games in a row. During his last five outings he is hitting .111 with a double and five walks.

Rays Player Leaders

• Yandy Diaz has accumulated a team-high OBP (.420), while pacing the Rays in hits (28). He's batting .326 and slugging.
• Including all qualified players, he ranks ninth in batting average, while his on-base percentage is eighth and he is 41st in slugging.
• Junior Caminero is hitting .250 with three doubles, five home runs and 12 walks. He's slugging .455 with an on-base percentage of .337.
• His batting average ranks 84th among all qualified players, his on-base percentage ranks 80th, and he is 61st in slugging.
• Jonathan Aranda is batting .225 with four doubles, three home runs and 16 walks.
• Chandler Simpson's .382 slugging percentage leads his team.

Reds vs Rays Head to Head

• 4/20/2026: 6-1 CIN (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/27/2025: 2-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/26/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/25/2025: 7-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/28/2024: 2-1 TB (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/27/2024: 4-0 TB (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/26/2024: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/19/2023: 8-0 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 4/18/2023: 10-0 TB (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/17/2023: 8-1 CIN (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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