Rays vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 12:12 p.m.

The MLB slate on Thursday includes the Tampa Bay Rays facing the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Rays vs Orioles Game Info

• Tampa Bay Rays (77-81) vs. Baltimore Orioles (74-84)
• Date: Thursday, September 25, 2025
• Time: 1:05 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and FDSSUN

Rays vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-118) | BAL: (-100)
• Spread: TB: -1.5 (+142) | BAL: +1.5 (-172)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Rays vs Orioles Probable Starting Pitchers

Probable Pitchers: Drew Rasmussen (Rays) - 10-5, 2.80 ERA vs Cade Povich (Orioles) - 3-8, 5.06 ERA

The probable pitchers are Drew Rasmussen (10-5) for the Rays and Cade Povich (3-8) for the Orioles. Rasmussen's team is 14-13-0 against the spread in his starts this season. When Rasmussen starts a game and his team is the favorite on the moneyline, they have a record of 8-8. The Orioles are 5-14-0 ATS in Povich's 19 starts with a set spread. The Orioles have been the underdog on the moneyline in nine of Povich's starts this season, and they went 2-7 in those matchups.

Rays vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (56.2%)

Rays vs Orioles Moneyline

• Baltimore is a -100 underdog on the moneyline, while Tampa Bay is a -118 favorite on the road.

Rays vs Orioles Spread

• The Rays are favored by 1.5 runs on the road versus the Orioles. The Rays are +142 to cover the spread, while the Orioles are -172.

Rays vs Orioles Over/Under

• The over/under for Rays-Orioles on Sept. 25 is 8.5. The over is -110, and the under is -110.

Bet on Tampa Bay Rays vs. Baltimore Orioles on FanDuel today!

Rays vs Orioles Betting Trends

• The Rays have won in 39, or 54.9%, of the 71 contests they have been named as odds-on favorites in this year.
• This year Tampa Bay has won 35 of 61 games when listed as at least -118 on the moneyline.
• The Rays and their opponents have hit the over in 67 of their 153 games with a total set by oddsmakers this season.
• The Rays are 68-85-0 against the spread in their 153 games that had a posted line this season.
• The Orioles have won 40 of the 89 games they were the moneyline underdog this season (44.9%).
• When playing as a moneyline underdog with odds of -100 or longer, Baltimore has a 30-40 record (winning 42.9% of its games).
• In the 155 games bookmakers have set an over/under for the Orioles, they have combined with opponents to go over the total 63 times (63-87-5).
• The Orioles have collected a 74-81-0 record against the spread this season.

Rays Player Leaders

• Junior Caminero has 152 hits, which leads Tampa Bay hitters this season, while batting .259 with 72 extra-base hits. He has an on-base percentage of .304 and a slugging percentage of .532.
• Among qualifying batters, he ranks 69th in batting average, his on-base percentage ranks 119th, and he is ninth in slugging.
• Yandy Diaz leads the Rays with an OPS of .851. He has a slash line of .301/.366/.485 this season.
• He ranks seventh in batting average, 14th in on-base percentage and 23rd in slugging in the majors.
• Brandon Lowe has collected 129 base hits, an OBP of .308 and a slugging percentage of .482 this season.
• Chandler Simpson has been key for Tampa Bay with 121 hits, an OBP of .331 plus a slugging percentage of .349.
• Simpson brings a three-game hitting streak into this game. In his last five games he is hitting .364 with a double and two RBIs.

Orioles Player Leaders

• Gunnar Henderson has racked up an on-base percentage of .347, a slugging percentage of .434, and has 153 hits, all club-highs for the Orioles (while batting .272).
• Including all qualifying players in the majors, his batting average places him 36th, his on-base percentage is 44th, and he is 70th in slugging.
• Jackson Holliday is batting .245 with 21 doubles, three triples, 17 home runs and 54 walks. He's slugging .381 with an on-base percentage of .316.
• Including all qualifying players, he ranks 104th in batting average, 100th in on-base percentage and 122nd in slugging percentage.
• Jordan Westburg is batting .264 with 10 doubles, a triple, 15 home runs and 17 walks.
• Adley Rutschman is hitting .222 with 16 doubles, a triple, nine home runs and 38 walks.

Rays vs Orioles Head to Head

• 9/24/2025: 6-2 TB (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/23/2025: 6-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/20/2025: 5-3 BAL (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/19/2025: 4-3 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/18/2025: 11-1 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/29/2025: 5-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/28/2025: 11-3 TB (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/27/2025: 22-8 BAL (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/19/2025: 4-1 BAL (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/18/2025: 12-8 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)

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