Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for April 27

Odds updated as of 6:14 p.m.

The Monday schedule in MLB includes a matchup between the Pittsburgh Pirates and the St. Louis Cardinals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (16-12) vs. St. Louis Cardinals (14-13)
• Date: Monday, April 27, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT+ and Cardinals.TV

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-122) | STL: (+104)
• Spread: PIT: -1.5 (+164) | STL: +1.5 (-200)
• Total: 8 -- Over: (-118) | Under: (-104)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Mason Montgomery (Pirates) - 1-0, 3.97 ERA vs Dustin May (Cardinals) - 3-2, 5.84 ERA

This contest's pitching matchup is set, as the Pirates will send Mason Montgomery (1-0) to the mound, while Dustin May (3-2) will answer the bell for the Cardinals. Montgomery helped his team cover the spread in his only opportunity this season as a starter. Montgomery's team won his only start as a favorite this season. When May starts, the Cardinals have gone 3-2-0 against the spread. The Cardinals are 2-2 in May's four starts this season that they were the underdog on the moneyline.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (56.4%)

Pirates vs Cardinals Moneyline

• The moneyline numbers for Pirates vs. Cardinals reveal Pittsburgh as the favorite (-122) and St. Louis as the underdog (+104) on the road.

Pirates vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-200 to cover), and Pittsburgh is +164 to cover the runline.

Pirates vs Cardinals Over/Under

• An over/under of 8 has been set for Pirates-Cardinals on April 27, with the over being -118 and the under -104.

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Pirates vs Cardinals Betting Trends

• The Pirates have come away with 11 wins in the 15 contests they have been listed as the favorites in this season.
• This season Pittsburgh has been victorious six times in 10 chances when named as a favorite of at least -122 on the moneyline.
• The Pirates and their opponents have gone over in 15 of their 28 games with a total set by sportsbooks this season.
• The Pirates are 17-11-0 against the spread in their 28 games with a line set by sportsbooks this season.
• The Cardinals have won 50% of the games this season they were the underdog on the moneyline (12-12).
• St. Louis is 9-9 (winning 50% of its games) when it has played as a moneyline underdog of +104 or longer.
• The Cardinals have played in 27 games with a set over/under, and have combined with opponents to go over the total 14 times (14-12-1).
• The Cardinals have a 15-12-0 record ATS this season (covering 55.6% of the time).

Pirates Player Leaders

• Oneil Cruz has an OPS of .838, fueled by an OBP of .320 and a team-best slugging percentage of .518 this season. He has a .259 batting average.
• Among qualified hitters in the majors, he ranks 68th in batting average, 108th in on-base percentage, and 25th in slugging.
• Ryan O'Hearn is slashing .315/.404/.489 this season and leads the Pirates with an OPS of .893.
• He is 12th in batting average, 10th in on-base percentage and 33rd in slugging in MLB.
• Brandon Lowe has 23 hits and is batting .247 this season.
• Lowe brings a two-game hitting streak into this matchup. In his last five games he is hitting .130 with a double, a walk and an RBI.
• Bryan Reynolds has three home runs, 17 RBI and a batting average of .242 this season.

Cardinals Player Leaders

• Jordan Walker has a team-high slugging percentage (.566) while leading the Cardinals in hits (28). He's batting .283 and with an on-base percentage of .360.
• Including all qualifying hitters in the big leagues, his batting average puts him 37th, his on-base percentage is 40th, and he is eighth in slugging.
• JJ Wetherholt has two doubles, five home runs and 15 walks while hitting .238. He's slugging .406 with an on-base percentage of .363.
• Including all qualifying players, he ranks 97th in batting average, 35th in on-base percentage and 88th in slugging percentage.
• Alec Burleson has six doubles, three home runs and 13 walks while hitting .245.
• Ivan Herrera's .403 OBP paces his team.

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