Penn State vs Oregon Prediction, Odds, Picks, Best Bets for Week 5 2025

College football's Saturday slate includes the Penn State Nittany Lions taking on the Oregon Ducks.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding today's NCAA football betting odds.

Penn State vs Oregon Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (-172) | Oregon: (+142)
• Spread: Penn State: -3.5 (-114) | Oregon: +3.5 (-106)
• Total: 53.5 -- Over: (-110) | Under: (-110)

Penn State vs Oregon Betting Trends

• Penn State is winless against the spread this year.
• Penn State has no wins ATS (0-3) as a 3.5-point favorite or greater this year.
• Two of Penn State's three games have hit the over.
• Oregon has won twice against the spread this season.
• A pair of Oregon four games in 2025 have gone over the point total.

Penn State vs Oregon Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (69.5%)

Penn State vs Oregon Point Spread

Oregon is listed as an underdog by 3.5 points (-106 odds), and Penn State, the favorite, is -114 to cover.

Penn State vs Oregon Over/Under

Penn State versus Oregon, on Sept. 27, has an over/under of 53.5, with the over being -110 and the under -110.

Penn State vs Oregon Moneyline

The moneyline numbers for Penn State vs. Oregon reveal Penn State as the favorite (-172) and Oregon as the underdog (+142).

Penn State vs. Oregon Points Insights

Penn State vs. Oregon Game Info

• Game day: Saturday, September 27, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: University Park, Pennsylvania
• Stadium: West Shore Home Field at Beaver Stadium

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Check out even more in-depth Penn State vs. Oregon analysis on FanDuel Research.