Cardinals vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for April 6

Odds updated as of 6:12 p.m.

MLB action on Monday includes the St. Louis Cardinals playing the Washington Nationals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Cardinals vs Nationals Game Info

• St. Louis Cardinals (5-4) vs. Washington Nationals (3-6)
• Date: Monday, April 6, 2026
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: Nationals.TV and Cardinals.TV

Cardinals vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | WSH: (-102)
• Spread: STL: -1.5 (+138) | WSH: +1.5 (-166)
• Total: 8 -- Over: (-115) | Under: (-105)

Cardinals vs Nationals Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 1-0, 0.00 ERA vs Zack Littell (Nationals) - 0-1, 5.40 ERA

The Cardinals will give the nod to Andre Pallante (1-0) against the Nationals and Zack Littell (0-1). Pallante helped his team cover the spread in his only opportunity this season as a starter. This will be Pallante's first game as the moneyline favorite this season. Last season Littell and his team went 18-15-0 against the spread in games he pitched. Littell and his team finished with a 11-11 record in the 22 games he appeared in when they were the moneyline underdog a season ago.

Cardinals vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.7%)

Cardinals vs Nationals Moneyline

• St. Louis is a -116 favorite on the moneyline, while Washington is a -102 underdog at home.

Cardinals vs Nationals Spread

• The Cardinals are 1.5-run road favorites on the runline against the Nationals. The Cardinals are +138 to cover, and the Nationals are -166.

Cardinals vs Nationals Over/Under

• The over/under for Cardinals-Nationals on April 6 is 8. The over is -115, and the under is -105.

Bet on St. Louis Cardinals vs. Washington Nationals on FanDuel today!

Cardinals vs Nationals Betting Trends

• The Cardinals will be listed as the favorite for the first time this season.
• These are the best odds of a victory sportsbooks have given St. Louis this season, with a -116 moneyline set for this game.
• The Cardinals' games have gone over the total in four of their nine opportunities.
• The Cardinals have posted a record of 5-4-0 against the spread this season.
• The Nationals have been the underdog on the moneyline nine total times this season. They've finished 3-6 in those games.
• In games it has played as a moneyline underdog with odds of -102 or longer, Washington has a 3-6 record (winning just 33.3% of its games).
• The Nationals have played in nine games with an over/under set, and have combined with their opponents to go over the total seven times (7-2-0).
• The Nationals have covered 55.6% of their games this season, going 5-4-0 against the spread.

Cardinals Player Leaders

• Jordan Walker has nine hits and an OBP of .382 to go with a slugging percentage of .567. All three of those stats lead St. Louis hitters this season. He has a .300 batting average, as well.
• Among qualifying hitters, he ranks 39th in batting average, his on-base percentage ranks 41st, and he is 27th in slugging.
• Walker has picked up at least one hit in two games in a row. In his last five games he is hitting .235 with a home run, a walk and five RBIs.
• Alec Burleson has two doubles, a home run and six walks. He's batting .242 and slugging .394 with an on-base percentage of .350.
• Among qualifying batters, he is 84th in batting average, 70th in on-base percentage and 87th in slugging percentage.
• JJ Wetherholt leads St. Louis in slugging percentage (.364).
• Wetherholt brings a two-game hitting streak into this game. In his last five games he is batting .294 with two walks.
• Ivan Herrera is batting .226 with a .375 OBP and six RBI for St. Louis this season.
• Herrera has safely hit in six straight games. During his last nine outings he is batting .226 with three doubles, seven walks and six RBIs.

Nationals Player Leaders

• C.J. Abrams has put up a team-high OBP (.389), while pacing the Nationals in hits (nine). He's batting .290 and slugging.
• Including all the qualifying hitters in the big leagues, his batting average ranks 47th, his on-base percentage is 36th, and he is 22nd in slugging.
• Abrams takes a six-game hitting streak into this game. During his last eight outings he is batting .290 with three home runs, four walks and 12 RBIs.
• Joey Wiemer is batting .476 with a triple, two home runs and five walks. He's slugging .857 with an on-base percentage of .577.
• Luis Garcia has three doubles, a triple and a home run while batting .324.
• Daylen Lile paces his team with a .375 slugging percentage.

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