Padres vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 5:12 a.m.

The San Diego Padres versus the Colorado Rockies is on the MLB schedule for Wednesday.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Rockies Game Info

• San Diego Padres (82-69) vs. Colorado Rockies (56-95)
• Date: Wednesday, September 16, 2026
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: Rockies.TV and Padres.TV

Padres vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-166) | COL: (+140)
• Spread: SD: -1.5 (-108) | COL: +1.5 (-111)
• Total: 11.5 -- Over: (+100) | Under: (-122)

Padres vs Rockies Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Padres) - 12-8, 3.57 ERA vs Mason Adams (Rockies) - 0-0, 3.37 ERA

The probable starters are Robbie Ray (12-8) for the Padres and Mason Adams for the Rockies. Ray and his team have a record of 16-10-0 against the spread when he starts. When Ray starts a game and his team is the favorite on the moneyline, they have a record of 8-5. The Rockies have a 3-1-0 ATS record in Adams' four starts with a set spread. The Rockies have a 2-2 record in Adams' four starts this season when they were the moneyline underdog.

Padres vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (61.9%)

Padres vs Rockies Moneyline

• The moneyline numbers for Padres vs. Rockies reveal San Diego as the favorite (-166) and Colorado as the underdog (+140) despite being the home team.

Padres vs Rockies Spread

• The Padres are favored by 1.5 runs on the road against the Rockies. The Padres are -108 to cover the spread, while the Rockies are -111.

Padres vs Rockies Over/Under

• The over/under for Padres-Rockies on Sept. 16 is 11.5. The over is +100, and the under is -122.

Bet on San Diego Padres vs. Colorado Rockies on FanDuel today!

Padres vs Rockies Betting Trends

• The Padres have won in 43, or 58.9%, of the 73 contests they have been named as odds-on favorites in this year.
• This season San Diego has been victorious 11 times in 17 chances when named as a favorite of at least -166 on the moneyline.
• The Padres and their opponents have hit the over in 69 of their 151 games with a total set by oddsmakers this season.
• The Padres are 86-65-0 against the spread in their 151 games that had a posted line this season.
• The Rockies have won 53 of the 144 games they were listed as the moneyline underdog this season (36.8%).
• When it has played as a moneyline underdog with odds of +140 or longer, Colorado has gone 25-61 (29.1%).
• The Rockies have had an over/under set by bookmakers 148 times, and have combined with opponents to go over the total in 73 of those games (73-72-3).
• The Rockies have put together a 78-70-0 record against the spread this season (covering 52.7% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.356), slugging percentage (.465) and total hits (169) this season. He has a .288 batting average.
• Among qualified hitters in baseball, his batting average ranks 14th, his on-base percentage ranks 37th, and he is 36th in slugging.
• Tatis will look for his seventh straight game with a hit in this matchup. During his last 10 games he is batting .375 with a triple, four home runs, six walks and eight RBIs.
• Manny Machado is batting .222 with 22 doubles, 28 home runs and 74 walks. He's slugging .416 with an on-base percentage of .312.
• Among all qualifying batters, he ranks 126th in batting average, 101st in on-base percentage and 80th in slugging percentage.
• Machado heads into this game looking to extend his three-game hit streak. In his last five games he is batting .150 with two home runs, three walks and three RBIs.
• Jackson Merrill has 145 hits this season and has a slash line of .253/.302/.441.
• Merrill brings a six-game hitting streak into this game. During his last 10 outings he is hitting .425 with three doubles, a triple, three home runs, two walks and 13 RBIs.
• Xander Bogaerts is batting .223 with a .322 OBP and 54 RBI for San Diego this season.
• Bogaerts enters this matchup on a two-game hitting streak. During his last five outings he is hitting .333 with two doubles, a walk and two RBIs.

Rockies Player Leaders

• Jake McCarthy has 30 doubles, 10 triples, 15 home runs and 28 walks while batting .297. He's slugging .485 with an on-base percentage of .341.
• Including all the qualifying players in MLB, his batting average puts him ninth, his on-base percentage ranks 55th, and he is 22nd in slugging.
• TJ Rumfield leads his team with a .392 OBP, and has a club-best .455 slugging percentage. He has a batting average of .300.
• Including all qualifying hitters, he ranks seventh in batting average, fourth in on-base percentage and 43rd in slugging percentage.
• Hunter Goodman has 118 hits, a team-best for the Rockies.
• Kyle Karros is batting .259 with 21 doubles, three triples, 11 home runs and 49 walks.

Padres vs Rockies Head to Head

• 9/15/2026: 9-3 COL (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/14/2026: 8-7 SD (Favorite: Padres, Spread: -1.5, Total: 11.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/29/2026: 3-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 7/28/2026: 8-7 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 4/23/2026: 10-8 SD (Favorite: Padres, Spread: -1.5, Total: 10.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/22/2026: 8-3 COL (Favorite: Padres, Spread: -1.5, Total: 12, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/21/2026: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 11, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/12/2026: 7-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/11/2026: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/10/2026: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!