Astros vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 2:12 a.m.

The Houston Astros are among the MLB teams in action on Wednesday, up against the Kansas City Royals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Astros vs Royals Game Info

• Houston Astros (76-75) vs. Kansas City Royals (66-85)
• Date: Wednesday, September 16, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Royals.TV

Astros vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-146) | KC: (+124)
• Spread: HOU: -1.5 (+146) | KC: +1.5 (-176)
• Total: 8.5 -- Over: (-122) | Under: (+100)

Astros vs Royals Probable Starting Pitchers

Probable Pitchers: Cristian Javier (Astros) - 2-5, 5.50 ERA vs Daniel Lynch (Royals) - 5-5, 3.52 ERA

The probable starters are Cristian Javier (2-5) for the Astros and Daniel Lynch (5-5) for the Royals. Javier and his team are 4-6-0 ATS this season when he starts. Javier's team has a record of 2-4 this season when he starts and they are the favorite on the moneyline. The Royals have gone 2-4-0 against the spread when Lynch starts. The Royals are 2-2 in Lynch's four starts this season that they were the underdog on the moneyline.

Astros vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (56.7%)

Astros vs Royals Moneyline

• Kansas City is a +124 underdog on the moneyline, while Houston is a -146 favorite at home.

Astros vs Royals Spread

• The Astros are 1.5-run home favorites on the runline against the Royals. The Astros are +146 to cover, and the Royals are -176.

Astros vs Royals Over/Under

• Astros versus Royals, on Sept. 16, has an over/under of 8.5, with the over being -122 and the under +100.

Bet on Houston Astros vs. Kansas City Royals on FanDuel today!

Astros vs Royals Betting Trends

• The Astros have been victorious in 34, or 53.1%, of the 64 contests they have been chosen as favorites in this season.
• This season Houston has been victorious seven times in 20 chances when named as a favorite of at least -146 on the moneyline.
• The Astros and their opponents have gone over the total this season in 75 of their 151 opportunities.
• The Astros are 76-75-0 against the spread in their 151 games that had a posted line this season.
• The Royals have won 39.8% of the games this season they were the moneyline underdog (37-56).
• When playing as a moneyline underdog with odds of +124 or longer, Kansas City has a 13-23 record (winning just 36.1% of its games).
• The Royals have had an over/under set by bookmakers 144 times, and have combined with opponents to go over the total in 65 of those games (65-76-3).
• The Royals have a 74-70-0 record against the spread this season.

Astros Player Leaders

• Yordan Alvarez has 163 hits and an OBP of .429 to go with a slugging percentage of .594. All three of those stats are tops among Houston hitters this season. He has a .310 batting average, as well.
• Among all qualified batters in MLB, his batting average ranks second, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes is hitting .258 with 26 doubles, a triple, 21 home runs and 64 walks. He's slugging .432 with an on-base percentage of .357.
• Among qualifying batters, he ranks 66th in batting average, 35th in on-base percentage and 63rd in slugging percentage.
• Christian Walker has 119 hits this season and has a slash line of .223/.297/.415.
• Jose Altuve is batting .243 with a .303 OBP and 44 RBI for Houston this season.

Royals Player Leaders

• Bobby Witt Jr. has accumulated an on-base percentage of .359 and a slugging percentage of .447. Both lead the Royals. He's batting .280.
• Including all qualified hitters, he is 22nd in batting average, while his on-base percentage is 32nd and he is 49th in slugging.
• Witt hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .263 with a home run, three walks and three RBIs.
• Carter Jensen is batting .232 with 32 doubles, two triples, 24 home runs and 62 walks. He's slugging .452 with an on-base percentage of .319.
• He is currently 110th in batting average, 85th in on-base percentage and 47th in slugging percentage among all qualified hitters.
• Jac Caglianone has accumulated 134 hits, a team-best for the Royals.
• Salvador Perez is batting .231 with 23 doubles, a triple, 19 home runs and 23 walks.

Astros vs Royals Head to Head

• 9/15/2026: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2026: 4-0 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/13/2026: 8-7 HOU (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2026: 10-8 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/13/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/12/2025: 7-5 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/27/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/26/2025: 2-0 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/25/2025: 2-0 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)

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