Astros vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 8:12 p.m.

The MLB schedule on Wednesday includes the Houston Astros taking on the Kansas City Royals.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Royals Game Info

• Houston Astros (76-75) vs. Kansas City Royals (66-85)
• Date: Wednesday, September 16, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Royals.TV

Astros vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | KC: (+136)
• Spread: HOU: -1.5 (+126) | KC: +1.5 (-152)
• Total: 8.5 -- Over: (-124) | Under: (+102)

Astros vs Royals Probable Starting Pitchers

Probable Pitchers: Cristian Javier (Astros) - 2-5, 5.50 ERA vs Daniel Lynch (Royals) - 5-5, 3.52 ERA

The probable pitchers are Cristian Javier (2-5) for the Astros and Daniel Lynch (5-5) for the Royals. Javier and his team have a record of 4-6-0 against the spread when he starts. Javier's team has a record of 2-4 this season when he starts and they are the favorite on the moneyline. The Royals have a 2-4-0 ATS record in Lynch's six starts with a set spread. The Royals have been the moneyline underdog in four of Lynch's starts this season, and they went 2-2 in those games.

Astros vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.2%)

Astros vs Royals Moneyline

• The moneyline numbers for Astros vs. Royals reveal Houston as the favorite (-162) and Kansas City as the underdog (+136) on the road.

Astros vs Royals Spread

• The Royals are +1.5 on the run line against the Astros. The Royals are -152 to cover, and the Astros are +126.

Astros vs Royals Over/Under

• The over/under for the Astros versus Royals game on Sept. 16 has been set at 8.5, with -124 odds on the over and +102 odds on the under.

Bet on Houston Astros vs. Kansas City Royals on FanDuel today!

Astros vs Royals Betting Trends

• The Astros have come away with 34 wins in the 64 contests they have been listed as the favorites in this season.
• This season Houston has come away with a win seven times in 16 chances when named as a favorite of at least -162 on the moneyline.
• The Astros and their opponents have hit the over in 75 of their 151 games with a total set by oddsmakers this season.
• The Astros have posted a record of 76-75-0 against the spread this season.
• The Royals have won 39.8% of the games this season they were the moneyline underdog (37-56).
• Kansas City is 7-15 (winning only 31.8% of its games) when playing as a moneyline underdog of +136 or longer.
• The Royals have had an over/under set by bookmakers 144 times, and have combined with opponents to go over the total in 65 of those games (65-76-3).
• The Royals have collected a 74-70-0 record ATS this season (covering 51.4% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston with 163 hits and an OBP of .429, plus a team-best slugging percentage of .594. He's batting .310.
• Among qualified batters, he ranks second in batting average, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes is hitting .258 with 26 doubles, a triple, 21 home runs and 64 walks. He's slugging .432 with an on-base percentage of .357.
• He is 66th in batting average, 35th in on-base percentage and 63rd in slugging in the majors.
• Christian Walker is batting .223 with a .415 slugging percentage and 80 RBI this year.
• Jeremy Pena is batting .273 with a .325 OBP and 49 RBI for Houston this season.

Royals Player Leaders

• Bobby Witt Jr. has put up an on-base percentage of .359 and a slugging percentage of .447. Both lead the Royals. He's batting .280.
• Including all qualifying hitters in MLB, he ranks 22nd in batting average, 33rd in on-base percentage and 49th in slugging percentage.
• Witt takes a three-game hitting streak into this matchup. During his last five outings he is hitting .263 with a home run, three walks and three RBIs.
• Carter Jensen is batting .232 with 32 doubles, two triples, 24 home runs and 62 walks. He's slugging .452 with an on-base percentage of .319.
• His batting average is 110th among all qualified players, his on-base percentage ranks 86th, and he is 45th in slugging.
• Jac Caglianone has racked up 134 hits, a team-high for the Royals.
• Salvador Perez is batting .231 with 23 doubles, a triple, 19 home runs and 23 walks.

Astros vs Royals Head to Head

• 9/15/2026: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2026: 4-0 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/13/2026: 8-7 HOU (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2026: 10-8 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/13/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/12/2025: 7-5 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/27/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/26/2025: 2-0 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/25/2025: 2-0 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)

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