Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 6:12 p.m.

The MLB slate on Tuesday includes the San Diego Padres facing the Cincinnati Reds.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Padres vs Reds Game Info

• San Diego Padres (73-65) vs. Cincinnati Reds (65-73)
• Date: Tuesday, September 1, 2026
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and Padres.TV

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-136) | CIN: (+116)
• Spread: SD: -1.5 (+114) | CIN: +1.5 (-137)
• Total: 9 -- Over: (-120) | Under: (-102)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 10-6, 4.02 ERA vs Nick Lodolo (Reds) - 3-3, 5.24 ERA

The Padres will call on Randy Vasquez (10-6) versus the Reds and Nick Lodolo (3-3). Vasquez's team is 15-6-0 against the spread in his starts this season. Vasquez's team has been victorious in 77.8% of the games he's started as the moneyline favorite with a record of 7-2. The Reds are 6-10-0 ATS in Lodolo's 16 starts that had a set spread. The Reds have a 5-6 record in Lodolo's 11 starts this season when they were the moneyline underdog.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.2%)

Padres vs Reds Moneyline

• Cincinnati is a +116 underdog on the moneyline, while San Diego is a -136 favorite on the road.

Padres vs Reds Spread

• The Padres are at the Reds and are favored by 1.5 runs (+114 to cover) on the runline. Cincinnati is -137 to cover.

Padres vs Reds Over/Under

• The over/under for Padres-Reds on Sept. 1 is 9. The over is -120, and the under is -102.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have been victorious in 35, or 57.4%, of the 61 contests they have been chosen as favorites in this season.
• This year San Diego has won 19 of 28 games when listed as at least -136 on the moneyline.
• The Padres and their opponents have gone over the total this season in 61 of their 138 opportunities.
• The Padres are 81-57-0 against the spread in their 138 games that had a posted line this season.
• The Reds have won 43 of the 91 games they were the underdog on the moneyline this season (47.3%).
• Cincinnati is 18-23 (winning 43.9% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Reds have had an over/under set by oddsmakers 135 times, and have combined with opponents to go over the total in 72 of those games (72-61-2).
• The Reds have a 69-66-0 record against the spread this season (covering 51.1% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.349), slugging percentage (.438) and total hits (150) this season. He has a .281 batting average.
• Among qualified hitters, he is 24th in batting average, his on-base percentage ranks 42nd, and he is 53rd in slugging.
• Manny Machado is batting .220 with 21 doubles, 24 home runs and 65 walks. He's slugging .405 with an on-base percentage of .307.
• He ranks 125th in batting average, 108th in on-base percentage and 87th in slugging in MLB.
• Machado has picked up a hit in three games in a row. In his last five games he is batting .381 with a double, two walks and two RBIs.
• Jackson Merrill is batting .241 with a .419 slugging percentage and 70 RBI this year.
• Merrill enters this game with two games in a row with at least one hit. In his last five games he is batting .368 with a double, a triple, a home run, three walks and four RBIs.
• Xander Bogaerts is batting .217 with a .316 OBP and 51 RBI for San Diego this season.
• Bogaerts heads into this matchup on a two-game hitting streak. In his last five games he is hitting .176 with a double, a walk and four RBIs.

Reds Player Leaders

• Sal Stewart has put up a slugging percentage of .489 and has 141 hits, both team-high numbers for the Reds. He's batting .266 and with an on-base percentage of .337.
• Including all qualifying hitters, he is 51st in batting average, while his on-base percentage is 62nd and he is 23rd in slugging.
• Stewart brings a four-game hitting streak into this game. During his last five outings he is batting .350 with a double, three home runs, two walks and six RBIs.
• Elly De La Cruz's .351 on-base percentage paces his team. He has a batting average of .270 while slugging .477.
• He is currently 45th in batting average, 40th in on-base percentage and 26th in slugging percentage among all qualified batters.
• JJ Bleday is hitting .216 with 14 doubles, two triples, 21 home runs and 64 walks.
• Tyler Stephenson is batting .251 with 19 doubles, 14 home runs and 41 walks.

Padres vs Reds Head to Head

• 8/31/2026: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 6/10/2026: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/9/2026: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/8/2026: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 2-1 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/9/2025: 4-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/8/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)

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