Cavaliers vs. 76ers Prediction: NBA Picks and Prop Bets (Oct. 22)

Cavs vs. 76ers Top Bets at a Glance

• Under 235.5 Points (-110)
• Anfernee Simons to Score 10+ Points (+110)

The Cleveland Cavaliers and Philadelphia 76ers square off Thursday night in one of only two games on the NBA schedule, putting plenty of attention on this Eastern Conference matchup.

Cleveland enters the new season with championship aspirations while Philadelphia — also among the title contenders — will look to build off its opening-night victory and defend home court.

Let's break down the best Cavaliers vs. 76ers bets and picks for tonight's game.

You can also check out our player news page to stay up to date with injury news.

Please note lines are subject to change throughout the day after this article is published. Bets in this article may be pulled from our other NBA content.

76ers vs. Cavs Prediction, Picks and Props

Anfernee Simons to Score 10+ Points (+110)

Anfernee Simons doesn't need a huge workload to get over such a modest scoring line.

Simons has averaged at least 17.3 points per game in each of the past five seasons, including 19.3 points per game last year. His role is smaller now on this Philadelphia roster, but he remains an aggressive perimeter scorer who can pile up points quickly from beyond the arc.

Even limited to a bench role, Simons should have opportunities to operate with the Sixers’ second unit and provide instant offense. We saw that in Tuesday’s opener as Simons got 10 shots, hitting five of them. Of those 10 attempts, eight game from downtown. He finished with 13 points.

Simons to get to double digits tonight is my favorite player prop of tonight’s slate.

Under 235.5 Points (-110)

I'm siding with the under in the Cleveland Cavaliers' season opener against the Philadelphia 76ers.

Philadelphia opened its campaign with a 106-100 win over the New York Knicks, meaning the two teams combined for only 206 points. That gives us at least some early evidence that the Sixers can drag games into a more manageable scoring environment, and Philly’s team — on paper — has the size to be a force defensively.

Cleveland certainly has enough offensive firepower to threaten this number, particularly with Donovan Mitchell leading the backcourt, but a total of 235.5 gives us some cushion. The Cavs don't necessarily need to struggle offensively for the under to cash.

With Philadelphia coming off a relatively low-scoring opener and Cleveland playing its first regular-season game, there could also be some early-season offensive rust. That makes the under appealing at such an elevated number.

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NBA Betting Frequently Asked Questions

What is the point spread in NBA betting?

The point spread is a handicap applied to the favored team to level the playing field. For example, if the Lakers are -6.5 against the Celtics, the Lakers must win by 7 or more points for a bet on them to pay out. A bet on the Celtics wins if Boston wins outright or loses by 6 points or fewer.

What does the moneyline mean in NBA betting?

A moneyline bet is a straight-up wager on which team wins — no spread involved. Odds use American format: a favorite is listed with a minus sign (e.g., -180), meaning a wager of $180 would win $100. An underdog carries a plus sign (e.g., +155), meaning a $100 bet would return $155 profit.

What is an over/under (total) bet in the NBA?

FanDuel will set a projected combined score for both teams. You bet whether the actual total points will go Over or Under that number. For example, if the total is 224.5, an Over bet wins if both teams combine for 225 or more points.

What are NBA player props?

Player prop bets focus on individual statistical performances rather than game outcomes. Common NBA props include points scored, rebounds, assists, three-pointers made, steals, and combined stat lines (e.g., Points + Rebounds + Assists). You bet whether the player goes Over or Under the sportsbook's posted line.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author’s advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.