Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for June 27

Odds updated as of 7:13 a.m.

The San Diego Padres versus the Cincinnati Reds is on the MLB schedule for Friday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this matchup.

Padres vs Reds Game Info

• San Diego Padres (44-36) vs. Cincinnati Reds (42-39)
• Date: Friday, June 27, 2025
• Time: 7:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and SDPA

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-138) | CIN: (+118)
• Spread: SD: -1.5 (+114) | CIN: +1.5 (-137)
• Total: 9 -- Over: (-122) | Under: (-100)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 3-6, 4.43 ERA vs Nick Martínez (Reds) - 4-8, 4.40 ERA

The Padres will give the ball to Dylan Cease (3-6, 4.43 ERA), who is eyeing win No. 4 on the season, and the Reds will turn to Nick Martinez (4-8, 4.40 ERA). When Cease starts, his team is 8-8-0 against the spread this season. Cease's team has been victorious in 70% of the games he's started as the moneyline favorite with a record of 7-3. When Martinez starts, the Reds have gone 5-10-0 against the spread. The Reds have a 2-7 record in Martínez's nine starts this season when they were the moneyline underdog.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.2%)

Padres vs Reds Moneyline

• Looking at the moneyline for Padres-Reds, San Diego is the favorite at -138, and Cincinnati is +118 playing at home.

Padres vs Reds Spread

• The Padres are at the Reds and are favored by 1.5 runs (+114 to cover) on the runline. Cincinnati is -137 to cover.

Padres vs Reds Over/Under

• An over/under of 9 has been set for Padres-Reds on June 27, with the over being -122 and the under -100.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have been favorites in 40 games this season and have come away with the win 25 times (62.5%) in those contests.
• This season San Diego has come away with a win 19 times in 30 chances when named as a favorite of at least -138 on the moneyline.
• Contests with the Padres have gone over the total set by oddsmakers in 33 of 79 chances this season.
• The Padres are 42-37-0 against the spread in their 79 games with a line set by sportsbooks this season.
• The Reds have gone 23-22 in games they were listed as the moneyline underdog (winning 51.1% of those games).
• Cincinnati has gone 8-12 in games it has played as a moneyline underdog with odds of +118 or longer (40%).
• The Reds have played in 77 games with an over/under set, and have combined with their opponents to go over the total 34 times (34-41-2).
• The Reds have a 41-36-0 record against the spread this season.

Padres Player Leaders

• Manny Machado leads San Diego in OBP (.360), slugging percentage (.492) and total hits (91) this season. He has a .298 batting average.
• Among qualifying hitters, he ranks 16th in batting average, his on-base percentage ranks 32nd, and he is 26th in slugging.
• Fernando Tatis Jr. is batting .261 with 11 doubles, a triple, 15 home runs and 38 walks, while slugging .455 with an on-base percentage of .351.
• He ranks 71st in batting average, 47th in on-base percentage and 54th in slugging in MLB.
• Luis Arraez has collected 87 base hits, an OBP of .317 and a slugging percentage of .397 this season.
• Arraez has picked up a hit in 12 straight games. During his last 10 outings he is hitting .372 with a triple and four RBIs.
• Gavin Sheets is batting .263 with a .322 OBP and 46 RBI for San Diego this season.

Reds Player Leaders

• Elly De La Cruz has a team-best slugging percentage (.511) and leads the Reds in hits (86). He's batting .277 and with an on-base percentage of .351.
• Including all the qualifying players in the big leagues, his batting average ranks 44th, his on-base percentage is 47th, and he is 18th in slugging.
• De La Cruz brings a six-game hitting streak into this game. In his last 10 outings he is batting .341 with a double, two triples, three home runs, two walks and eight RBIs.
• TJ Friedl has a .372 OBP to pace his team. He has a batting average of .287 while slugging .426.
• Including all qualified hitters, he ranks 27th in batting average, 22nd in on-base percentage and 78th in slugging percentage.
• Gavin Lux is batting .266 with 14 doubles, a triple, four home runs and 32 walks.
• Spencer Steer is batting .243 with 13 doubles, a triple, six home runs and 20 walks.

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