Padres vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for April 8

Odds updated as of 12:12 p.m.

Wednesday's slate in the MLB includes a matchup between the San Diego Padres and the Pittsburgh Pirates.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Padres vs Pirates Game Info

• San Diego Padres (5-6) vs. Pittsburgh Pirates (7-4)
• Date: Wednesday, April 8, 2026
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Padres.TV

Padres vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-120) | PIT: (+102)
• Spread: SD: -1.5 (+150) | PIT: +1.5 (-182)
• Total: 7 -- Over: (-118) | Under: (-104)

Padres vs Pirates Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 0-1, 3.37 ERA vs Mitch Keller (Pirates) - 1-0, 1.50 ERA

This contest's pitching matchup is set, as the Padres will send Michael King (0-1) to the mound, while Mitch Keller (1-0) will take the ball for the Pirates. King has a record of 0-2-0 ATS in two starts with a spread this season. King's team lost his only start as a favorite this season. Keller has started two games with set spreads, and the Pirates went 1-1-0. The Pirates were the underdog on the moneyline for two Keller starts this season -- they split the games.

Padres vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.4%)

Padres vs Pirates Moneyline

• Looking at the moneyline for Padres-Pirates, San Diego is the favorite at -120, and Pittsburgh is +102 playing at home.

Padres vs Pirates Spread

• The Padres are at the Pirates and are favored by 1.5 runs (+150 to cover) on the runline. Pittsburgh is -182 to cover.

Padres vs Pirates Over/Under

• An over/under of 7 has been set for Padres-Pirates on April 8, with the over being -118 and the under -104.

Bet on San Diego Padres vs. Pittsburgh Pirates on FanDuel today!

Padres vs Pirates Betting Trends

• The Padres have been chosen as favorites in three games this year and have walked away with the win one time (33.3%) in those games.
• San Diego has been listed as a favorite of -120 or more on two occasions this season and split those games.
• The Padres and their opponents have hit the over in four of their 11 games with a total set by oddsmakers this season.
• The Padres have an against the spread record of 6-5-0 in 11 games with a line this season.
• The Pirates have been the moneyline underdog five total times this season. They've finished 2-3 in those games.
• Pittsburgh has gone 1-2 when it has played as a moneyline underdog with odds of +102 or longer (33.3%).
• The Pirates have played in 11 games with a set over/under, and have combined with opponents to go over the total six times (6-5-0).
• The Pirates have collected a 7-4-0 record against the spread this season (covering 63.6% of the time).

Padres Player Leaders

• Jackson Merrill leads San Diego in total hits (nine) this season while batting .225 with four extra-base hits. He has an on-base percentage of .279 and a slugging percentage of .425.
• Among all qualifying batters, he is 113th in batting average, his on-base percentage ranks 140th, and he is 75th in slugging.
• Ramon Laureano has nine hits, which ranks first among San Diego batters this season. He's batting .225 with four extra-base hits. He's also slugging .425 with an on-base percentage of .262.
• He is 113th in batting average, 156th in on-base percentage and 75th in slugging in MLB.
• Manny Machado has seven hits this season and a team-best OBP of .400.
• Xander Bogaerts leads San Diego in slugging percentage (.349) thanks to three extra-base hits.
• Bogaerts takes a three-game hitting streak into this game. In his last five games he is batting .316 with a double, a home run, two walks and an RBI.

Pirates Player Leaders

• Ryan O'Hearn has totaled 14 hits with a .489 on-base percentage and a .694 slugging percentage, all club-highs for the Pirates. He's batting .389.
• Including all the qualifying players in the majors, he is fourth in batting average, fourth in on-base percentage and sixth in slugging percentage.
• O'Hearn heads into this game on a four-game hitting streak. In his last five games he is hitting .353 with two doubles, a home run, four walks and five RBIs.
• Oneil Cruz is hitting .295 with a double, four home runs and two walks. He's slugging .591 with an on-base percentage of .340.
• Including all qualifying players, he is 42nd in batting average, 75th in on-base percentage and 16th in slugging percentage.
• Brandon Lowe has two doubles, three home runs and seven walks while hitting .243.
• Bryan Reynolds is hitting .233 with a double, two home runs and six walks.

Padres vs Pirates Head to Head

• 4/7/2026: 7-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 6, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/6/2026: 5-0 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 5-0 PIT (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/30/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/4/2025: 4-0 SD (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/2/2025: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 8-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/13/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/12/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)

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