Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 11

Odds updated as of 10:12 p.m.

In MLB action on Friday, the San Diego Padres face the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Giants Game Info

• San Diego Padres (78-68) vs. San Francisco Giants (62-85)
• Date: Friday, September 11, 2026
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: Apple TV+

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-156) | SF: (+132)
• Spread: SD: -1.5 (+114) | SF: +1.5 (-134)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Padres) - 11-8, 3.39 ERA vs Anthony Molina (Giants) - 3-0, 2.79 ERA

The probable starters are Robbie Ray (11-8) for the Padres and Anthony Molina (3-0) for the Giants. Ray and his team are 15-10-0 ATS this season when he starts. When Ray starts a game and his team is the favorite on the moneyline, they have a record of 7-5. Molina has started two games with set spreads, and the Giants covered in both opportunities. The Giants were the underdog on the moneyline for two Molina starts this season -- they won both.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (50.7%)

Padres vs Giants Moneyline

• San Francisco is a +132 underdog on the moneyline, while San Diego is a -156 favorite on the road.

Padres vs Giants Spread

• The Padres are favored by 1.5 runs on the road versus the Giants. The Padres are +114 to cover the spread, while the Giants are -134.

Padres vs Giants Over/Under

• Padres versus Giants on Sept. 11 has an over/under of 7.5 runs, with the odds on the over -115 and the under set at -105.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have been chosen as favorites in 68 games this year and have walked away with the win 39 times (57.4%) in those games.
• San Diego has a record of 12-7 when favored by -156 or more this year.
• The Padres' games have gone over the total in 64 of their 146 opportunities.
• In 146 games with a line this season, the Padres have a mark of 84-62-0 against the spread.
• The Giants are 37-61 in games they were the underdog on the moneyline (winning 37.8% of those games).
• San Francisco is 14-19 (winning 42.4% of its games) when it has played as a moneyline underdog of +132 or longer.
• In the 144 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 69 times (69-65-10).
• The Giants have gone 69-75-0 against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 161 hits and an OBP of .351, plus a team-best slugging percentage of .449. He's batting .284.
• He is 16th in batting average, 38th in on-base percentage, and 47th in slugging among all qualified hitters in MLB.
• Manny Machado is hitting .224 with 22 doubles, 26 home runs and 71 walks. He's slugging .414 with an on-base percentage of .314.
• His batting average ranks 120th among qualified players, his on-base percentage 95th, and his slugging percentage 77th.
• Jackson Merrill has 135 hits this season and has a slash line of .245/.295/.431.
• Ty France is batting .294 with a .363 OBP and 63 RBI for San Diego this season.
• France has hit safely in two games in a row. During his last five outings he is batting .278 with a double, two walks and an RBI.

Giants Player Leaders

• Rafael Devers has accumulated an on-base percentage of .340, a slugging percentage of .518, and has 142 hits, all club-bests for the Giants (while batting .258).
• He is 64th in batting average, 54th in on-base percentage and ninth in slugging percentage among all qualified hitters in the majors.
• Jung Hoo Lee paces his team with a .408 slugging percentage. He has a batting average of .281 with an on-base percentage of .324.
• His batting average is 23rd among all qualified players, his on-base percentage ranks 78th, and he is 84th in slugging.
• Bryce Eldridge has 21 doubles, 16 home runs and 55 walks while batting .268.
• Drew Gilbert is hitting .232 with 14 doubles, three triples, eight home runs and 34 walks.

Padres vs Giants Head to Head

• 8/2/2026: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/1/2026: 6-5 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 7/31/2026: 7-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 7/30/2026: 4-1 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/6/2026: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: -106)
• 5/5/2026: 10-5 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/4/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -194, Underdog Moneyline: +150)
• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)

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