White Sox vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 11

Odds updated as of 8:12 p.m.

The MLB schedule on Friday includes the St. Louis Cardinals facing the Chicago White Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (72-75) vs. Chicago White Sox (75-71)
• Date: Friday, September 11, 2026
• Time: 8:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CHSN

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | CHW: (-106)
• Spread: STL: +1.5 (-192) | CHW: -1.5 (+158)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 5-14, 5.57 ERA vs Anthony Kay (White Sox) - 9-8, 4.53 ERA

The probable starters are Matthew Liberatore (5-14) for the Cardinals and Anthony Kay (9-8) for the White Sox. Liberatore and his team are 13-14-0 ATS this season when he starts. Liberatore's team has a record of 5-4 this season when he starts and they are the favorite on the moneyline. When Kay starts, the White Sox have gone 18-8-0 against the spread. The White Sox have a 13-8 record in Kay's 21 starts this season when they were the moneyline underdog.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (50.3%)

Cardinals vs White Sox Moneyline

• Chicago is the underdog, -106 on the moneyline, while St. Louis is a -110 favorite at home.

Cardinals vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Cardinals. The White Sox are +158 to cover, while the Cardinals are -192 to cover as a 1.5-run underdog on the runline.

Cardinals vs White Sox Over/Under

• The over/under for Cardinals-White Sox on Sept. 11 is 7.5. The over is -120, and the under is -102.

Bet on St. Louis Cardinals vs. Chicago White Sox on FanDuel today!

Cardinals vs White Sox Betting Trends

• The Cardinals have been favorites in 47 games this season and have come away with the win 25 times (53.2%) in those contests.
• This season St. Louis has come away with a win 24 times in 46 chances when named as a favorite of at least -110 on the moneyline.
• Contests with the Cardinals have gone over the total set by sportsbooks in 65 of 143 chances this season.
• In 143 games with a line this season, the Cardinals have a mark of 77-66-0 against the spread.
• The White Sox have been the moneyline underdog 101 total times this season. They've finished 49-52 in those games.
• When playing as a moneyline underdog with odds of -106 or longer, Chicago has gone 48-53 (47.5%).
• The White Sox have combined with opponents to hit the over on the total 78 times this season for a 78-64-1 record against the over/under.
• The White Sox are 81-62-0 ATS this season.

Cardinals Player Leaders

• Alec Burleson has an OPS of .816, fueled by an OBP of .350 and a team-best slugging percentage of .467 this season. He has a .283 batting average.
• Among qualified hitters, he ranks 17th in batting average, his on-base percentage ranks 41st, and he is 34th in slugging.
• Jordan Walker has 157 hits to go with a slugging percentage of .489, both of which are tops among St. Louis hitters this season. He's batting .281 with an on-base percentage of .337.
• Among qualifying batters, he is 23rd in batting average, 56th in on-base percentage and 21st in slugging percentage.
• Ivan Herrera leads St. Louis in OBP (.360) this season, fueled by 138 hits.
• Herrera heads into this game with seven games in a row with at least one hit. During his last 10 outings he is hitting .333 with two doubles, two home runs, three walks and 11 RBIs.
• Nathan Church is batting .244 with a .288 OBP and 49 RBI for St. Louis this season.
• Church enters this game on a nine-game hitting streak. In his last 10 outings he is hitting .270 with a double, a walk and three RBIs.

White Sox Player Leaders

• Miguel Vargas has racked up 132 hits, a team-best for the White Sox. He's batting .248 and slugging .477 with an on-base percentage of .359.
• Including all qualified players, he is 81st in batting average, while his on-base percentage ranks 33rd and he is 26th in slugging.
• Sam Antonacci's .363 on-base percentage leads his team. He has a batting average of .265 while slugging .387.
• Including all qualifying players, he is 52nd in batting average, 24th in on-base percentage and 104th in slugging percentage.
• Chase Meidroth has put up a team-high .390 slugging percentage.
• Tristan Peters has 30 doubles, four triples, 12 home runs and 33 walks while batting .281.

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