Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for June 5

Odds updated as of 3:11 p.m.

The MLB slate on Thursday includes the San Diego Padres facing the San Francisco Giants.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Giants Game Info

• San Diego Padres (35-25) vs. San Francisco Giants (34-28)
• Date: Thursday, June 5, 2025
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SDPA

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-116) | SF: (-102)
• Spread: SD: -1.5 (+158) | SF: +1.5 (-192)
• Total: 7 -- Over: (-122) | Under: (-100)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 1-4, 4.66 ERA vs Robbie Ray (Giants) - 7-1, 2.43 ERA

The probable starters are Dylan Cease (1-4) for the Padres and Robbie Ray (7-1) for the Giants. Cease and his team are 6-6-0 ATS this season when he starts. When Cease starts a game and his team is the favorite on the moneyline, they have a record of 5-3. The Giants are 8-4-0 against the spread when Ray starts. The Giants won each of Ray's four starts this season that they were the underdog on the moneyline.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (51.5%)

Padres vs Giants Moneyline

• The Padres vs Giants moneyline has San Diego as a -116 favorite, while San Francisco is a -102 underdog at home.

Padres vs Giants Spread

• The Giants are hosting the Padres, and are +1.5 on the runline. The Giants are +158 to cover the spread, and the Padres are -192.

Padres vs Giants Over/Under

• Padres versus Giants, on June 5, has an over/under of 7, with the over being -122 and the under -100.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have won in 20, or 60.6%, of the 33 contests they have been named as odds-on favorites in this year.
• San Diego has a record of 20-13 in contests when oddsmakers favor them by -116 or more on the moneyline.
• The Padres and their opponents have hit the over in 25 of their 59 games with a total set by oddsmakers this season.
• The Padres have an against the spread mark of 31-28-0 in 59 games with a line this season.
• The Giants have been the moneyline underdog 22 total times this season. They've gone 11-11 in those games.
• San Francisco has gone 7-9 when it has played as a moneyline underdog with odds of -102 or longer (43.8%).
• The Giants have combined with opponents to hit the over on the total 28 times this season for a 28-33-1 record against the over/under.
• The Giants have put together a 28-34-0 record against the spread this season (covering 45.2% of the time).

Padres Player Leaders

• Fernando Tatis Jr. has eight doubles, a triple, 13 home runs and 25 walks while hitting .273. He has an on-base percentage of .345 and a slugging percentage of .485.
• Among all qualified hitters in baseball, he ranks 54th in batting average, 55th in on-base percentage, and 37th in slugging.
• Tatis has recorded a base hit in three straight games. During his last five outings he is hitting .316 with a double and three walks.
• Manny Machado leads the Padres with an OPS of .864. He has a slash line of .314/.380/.484 this season.
• His batting average ranks 10th among qualified players, his on-base percentage 21st, and his slugging percentage 39th.
• Machado heads into this game looking to extend his two-game hit streak. In his last five games he is batting .316 with a home run, two walks and four RBIs.
• Luis Arraez is batting .281 with a .406 slugging percentage and 21 RBI this year.
• Gavin Sheets leads San Diego with 49 hits, batting .263 this season with 19 extra-base hits.

Giants Player Leaders

• Jung Hoo Lee has 16 doubles, two triples, six home runs and 15 walks while batting .274. He's slugging .435 with an on-base percentage of .319.
• Including all the qualified hitters in MLB, he ranks 50th in batting average, 93rd in on-base percentage and 68th in slugging percentage.
• Heliot Ramos paces his team with 68 hits and a .356 OBP, with a team-best .494 slugging percentage. He has a batting average of .292.
• Including all qualifying hitters, he ranks 19th in batting average, 39th in on-base percentage and 29th in slugging percentage.
• Wilmer Flores is hitting .250 with four doubles, 10 home runs and 18 walks.
• Matt Chapman has 10 doubles, 11 home runs and 39 walks while batting .236.

Padres vs Giants Head to Head

• 6/4/2025: 6-5 SF (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/3/2025: 3-2 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/2/2025: 1-0 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/30/2025: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/29/2025: 7-4 SD (Favorite: Giants, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2024: 4-3 SD (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/14/2024: 8-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/13/2024: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/8/2024: 7-6 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/7/2024: 6-3 SF (Favorite: Padres, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

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