Padres vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for April 18

Odds updated as of 9:12 p.m.

The San Diego Padres will take on the Los Angeles Angels in MLB action on Saturday.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Angels Game Info

• San Diego Padres (13-7) vs. Los Angeles Angels (11-10)
• Date: Saturday, April 18, 2026
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and Padres.TV

Padres vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-118) | LAA: (+100)
• Spread: SD: -1.5 (+146) | LAA: +1.5 (-178)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Padres vs Angels Probable Starting Pitchers

Probable Pitchers: German Marquez (Padres) - 2-1, 5.54 ERA vs Yusei Kikuchi (Angels) - 0-2, 7.50 ERA

This contest's pitching matchup is set, as the Padres will send German Marquez (2-1) to the mound, while Yusei Kikuchi (0-2) will get the nod for the Angels. Marquez and his team have a record of 2-1-0 against the spread when he starts. Marquez's team won his only start as a favorite this season. When Kikuchi starts, the Angels are 2-2-0 against the spread. The Angels have been the moneyline underdog in four of Kikuchi's starts this season, and they went 1-3 in those matchups.

Padres vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (54.2%)

Padres vs Angels Moneyline

• Looking at the moneyline for Angels-Padres, Los Angeles is the underdog at +100, and San Diego is -118 playing on the road.

Padres vs Angels Spread

• The Padres are at the Angels and are favored by 1.5 runs on the spread. The Padres are +146 to cover the runline, with the Angels being -178.

Padres vs Angels Over/Under

• A combined run total of 8.5 has been set for Padres-Angels on April 18, with the over at -105 and the under at -115.

Bet on San Diego Padres vs. Los Angeles Angels on FanDuel today!

Padres vs Angels Betting Trends

• The Padres have come away with six wins in the eight contests they have been listed as the favorites in this season.
• San Diego has a record of 6-2 when favored by -118 or more this year.
• The Padres and their opponents have gone over the total this season in nine of their 20 opportunities.
• The Padres are 14-6-0 against the spread in their 20 games that had a posted line this season.
• The Angels have been the moneyline underdog 19 total times this season. They've gone 9-10 in those games.
• When playing as a moneyline underdog with odds of +100 or longer, Los Angeles has a 9-10 record (winning 47.4% of its games).
• In the 21 games oddsmakers have set an over/under for the Angels, they have combined with opponents to go over the total 12 times (12-9-0).
• The Angels are 13-8-0 ATS this season.

Padres Player Leaders

• Jackson Merrill is hitting .247 with six doubles, three home runs and six walks. He has an on-base percentage of .301 and a slugging percentage of .442.
• He is 87th in batting average, 133rd in on-base percentage, and 68th in slugging among all qualified batters in MLB.
• Ramon Laureano leads San Diego with 20 hits and a team-best slugging percentage of .551. He's batting .290 with an on-base percentage of .355.
• His batting average ranks 37th among qualified players, his on-base percentage 54th, and his slugging percentage 22nd.
• Laureano enters this matchup looking to extend his six-game hit streak. In his last 10 games he is hitting .316 with three doubles, a triple, two home runs, four walks and eight RBIs.
• Xander Bogaerts is batting .260 with a .411 slugging percentage and 13 RBI this year.
• Manny Machado leads San Diego with an OBP of .363 this season while batting .210 with 16 walks and 10 runs scored.
• Machado takes a two-game hitting streak into this game. In his last five games he is batting .250 with three walks and three RBIs.

Angels Player Leaders

• Mike Trout has accumulated an on-base percentage of .415 and has 17 hits, both team-best marks for the Angels. He's batting .236 and slugging .569.
• Including all the qualified hitters in the majors, his batting average puts him 104th, his on-base percentage ranks 12th, and he is 17th in slugging.
• Zach Neto is batting .247 with four doubles, five home runs and 14 walks. He's slugging .471 with an on-base percentage of .360.
• Including all qualifying hitters, he is 87th in batting average, 53rd in on-base percentage and 57th in slugging percentage.
• Jo Adell has racked up a slugging percentage of .430, a team-best for the Angels.
• Oswald Peraza is batting .286 with three doubles, four home runs and six walks.

Padres vs Angels Head to Head

• 4/17/2026: 8-0 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/14/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/13/2025: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/12/2025: 9-5 LAA (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 6/5/2024: 3-2 LAA (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/4/2024: 4-2 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/3/2024: 2-1 LAA (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/5/2023: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 7/4/2023: 8-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 7/3/2023: 10-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!