Orioles vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 28

Odds updated as of 6:11 p.m.

The Wednesday slate in MLB includes a matchup between the Baltimore Orioles and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Orioles vs Cardinals Game Info

• Baltimore Orioles (19-35) vs. St. Louis Cardinals (31-24)
• Date: Wednesday, May 28, 2025
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MLB Network, MASN, and FDSMW

Orioles vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-112) | STL: (-104)
• Spread: BAL: +1.5 (-194) | STL: -1.5 (+160)
• Total: 7.5 -- Over: (-124) | Under: (+102)

Orioles vs Cardinals Probable Starting Pitchers

Probable Pitchers: Cade Povich (Orioles) - 1-3, 4.86 ERA vs Miles Mikolas (Cardinals) - 4-2, 3.51 ERA

This contest's pitching matchup is set, as the Orioles will send Cade Povich (1-3) to the mound, while Miles Mikolas (4-2) will answer the bell for the Cardinals. When Povich starts, his team is 2-7-0 against the spread this season. Povich's team has been victorious in 40% of the games he's started as the moneyline favorite with a record of 2-3. When Mikolas starts, the Cardinals have gone 5-5-0 against the spread. The Cardinals have been the moneyline underdog in eight of Mikolas' starts this season, and they went 4-4 in those games.

Orioles vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.6%)

Orioles vs Cardinals Moneyline

• Baltimore is the favorite, -112 on the moneyline, while St. Louis is a -104 underdog on the road.

Orioles vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Orioles. The Cardinals are +160 to cover, while the Orioles are -194 to cover as a 1.5-run underdog on the runline.

Orioles vs Cardinals Over/Under

• Orioles versus Cardinals on May 28 has an over/under of 7.5 runs, with the odds on the over -124 and the under set at +102.

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Orioles vs Cardinals Betting Trends

• The Orioles have been victorious in nine, or 33.3%, of the 27 contests they have been chosen as favorites in this season.
• This season Baltimore has come away with a win nine times in 25 chances when named as a favorite of at least -112 on the moneyline.
• The Orioles and their opponents have hit the over in 27 of their 54 games with a total set by oddsmakers this season.
• In 54 games with a line this season, the Orioles have a mark of 18-36-0 against the spread.
• The Cardinals have won 19 of the 34 games they were the moneyline underdog this season (55.9%).
• St. Louis is 14-15 (winning 48.3% of its games) when playing as a moneyline underdog of -104 or longer.
• The Cardinals have played in 55 games with an over/under set, and have combined with their opponents to go over the total 28 times (28-25-2).
• The Cardinals have gone 31-24-0 ATS this season.

Orioles Player Leaders

• Ryan O'Hearn leads Baltimore in OBP (.428), slugging percentage (.558) and total hits (53) this season. He has a .340 batting average.
• Among all qualifying hitters, he ranks fifth in batting average, his on-base percentage ranks third, and he is eighth in slugging.
• O'Hearn will look for his eighth straight game with a hit in this contest. During his last 10 games he is batting .486 with three doubles, two home runs, five walks and seven RBIs.
• Cedric Mullins has nine doubles, 10 home runs and 23 walks. He's batting .226 and slugging .446 with an on-base percentage of .320.
• Among qualified hitters, his batting average ranks him 135th, his on-base percentage 98th, and his slugging percentage 60th.
• Gunnar Henderson has collected 49 base hits, an OBP of .325 and a slugging percentage of .447 this season.
• Adley Rutschman has five home runs, 15 RBI and a batting average of .211 this season.

Cardinals Player Leaders

• Lars Nootbaar has 10 doubles, eight home runs and 33 walks while hitting .249. He's slugging .411 with an on-base percentage of .354.
• Including all the qualified players in the big leagues, he ranks 98th in batting average, 43rd in on-base percentage and 89th in slugging percentage.
• Brendan Donovan has racked up 66 hits with a .390 OBP while slugging .463. Those stats all pace his team. He also has a batting average of .328.
• Including all qualifying hitters, he ranks seventh in batting average, 13th in on-base percentage and 45th in slugging percentage.
• Nolan Arenado is batting .238 with 10 doubles, a triple, six home runs and 18 walks.
• Masyn Winn has six doubles, six home runs and 18 walks while batting .261.

Orioles vs Cardinals Head to Head

• 5/27/2025: 7-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/26/2025: 5-2 BAL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/20/2024: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/13/2023: 1-0 STL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/12/2023: 5-2 STL (Favorite: Orioles, Spread: -1.5, Total: 11, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/11/2023: 11-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 10, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/11/2022: 10-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/10/2022: 5-3 BAL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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