Ole Miss vs LSU Prediction, Odds, Picks, Best Bets for Week 5 2025

The Ole Miss Rebels are among the college football squads busy on Saturday, versus the LSU Tigers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Ole Miss vs LSU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ole Miss: (-126) | LSU: (+105)
• Spread: Ole Miss: -2.5 (-104) | LSU: +2.5 (-118)
• Total: 57.5 -- Over: (-110) | Under: (-110)

Ole Miss vs LSU Betting Trends

• Ole Miss has three wins in four games against the spread this season.
• Against the spread as 2.5-point or better favorites, Ole Miss is 3-1.
• This season, three of Ole Miss' four games have go over the point total.
• LSU has posted two wins against the spread this year.
• LSU is unbeaten ATS (1-0) as a 2.5-point underdog or more this year.
• LSU has had one game (of four) go over the total this season.

Ole Miss vs LSU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Rebels win (70.5%)

Ole Miss vs LSU Point Spread

LSU is the underdog by 2.5 points against Ole Miss. LSU is -104 to cover the spread, and Ole Miss is -118.

Ole Miss vs LSU Over/Under

Ole Miss versus LSU, on Sept. 27, has an over/under of 57.5, with the over being -110 and the under -110.

Ole Miss vs LSU Moneyline

LSU is the underdog, +105 on the moneyline, while Ole Miss is a -126 favorite.

Ole Miss vs. LSU Points Insights

Ole Miss vs. LSU Game Info

• Game day: Saturday, September 27, 2025
• Game time: 3:30 p.m. ET
• TV channel: ABC
• Location: Oxford, Mississippi
• Stadium: Vaught-Hemingway Stadium

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Check out even more in-depth Ole Miss vs. LSU analysis on FanDuel Research.