Oklahoma vs LSU Prediction, Odds, Picks, Best Bets for Week 14 2025

The Oklahoma Sooners versus the LSU Tigers is on the college football schedule for Saturday.

We've got you covered, in terms of the most important info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Oklahoma vs LSU Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oklahoma: (-461) | LSU: (+360)
• Spread: Oklahoma: -10.5 (-104) | LSU: +10.5 (-118)
• Total: 36.5 -- Over: (-105) | Under: (-115)

Oklahoma vs LSU Betting Trends

• Oklahoma has seven wins in 11 games against the spread this season.
• Oklahoma owns one win ATS (1-2) as a 10.5-point favorite or greater this year.
• Oklahoma has had two games (out of 11) hit the over this year.
• Against the spread, LSU is 3-8-0 this season.
• LSU doesn't have a win ATS (0-1) as a 10.5-point underdog or more this season.
• LSU has played 11 games this season, and three of them have gone over the total.

Oklahoma vs LSU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Sooners win (75.4%)

Oklahoma vs LSU Point Spread

LSU is the underdog by 10.5 points against Oklahoma. LSU is -104 to cover the spread, and Oklahoma is -118.

Oklahoma vs LSU Over/Under

An over/under of 36.5 has been set for Oklahoma-LSU on Nov. 29, with the over being -105 and the under -115.

Oklahoma vs LSU Moneyline

The Oklahoma vs LSU moneyline has Oklahoma as a -461 favorite, while LSU is a +360 underdog.

Oklahoma vs. LSU Points Insights

Oklahoma vs. LSU Game Info

• Game day: Saturday, November 29, 2025
• Game time: 3:30 p.m. ET
• TV channel: ABC
• Location: Norman, Oklahoma
• Stadium: Gaylord Family Oklahoma Memorial Stadium

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