Ohio State vs Purdue Prediction, Odds, Picks, Best Bets for Week 11 2025

The college football slate on Saturday includes the Ohio State Buckeyes facing the Purdue Boilermakers.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Ohio State vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-10000) | Purdue: (+2400)
• Spread: Ohio State: -29.5 (-115) | Purdue: +29.5 (-105)
• Total: 49.5 -- Over: (-110) | Under: (-110)

Ohio State vs Purdue Betting Trends

• Ohio State is 7-1-0 against the spread this season.
• Ohio State has yet to lose ATS (1-0) as a 29.5-point favorite or greater this year.
• There have been three Ohio State games (of eight) that hit the over this season.
• Purdue has beaten the spread four times in nine games.
• Two Purdue games (of nine) have gone over the point total this year.

Ohio State vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (95.4%)

Ohio State vs Purdue Point Spread

Ohio State is favored by 29.5 points over Purdue. Ohio State is -115 to cover the spread, with Purdue being -105.

Ohio State vs Purdue Over/Under

An over/under of 49.5 has been set for Ohio State-Purdue on Nov. 8, with the over being -110 and the under -110.

Ohio State vs Purdue Moneyline

Ohio State is the favorite, -10000 on the moneyline, while Purdue is a +2400 underdog.

Ohio State vs. Purdue Points Insights

Ohio State vs. Purdue Game Info

• Game day: Saturday, November 8, 2025
• Game time: 1 p.m. ET
• TV channel: BTN
• Location: West Lafayette, Indiana
• Stadium: Ross-Ade Stadium

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Check out even more in-depth Ohio State vs. Purdue analysis on FanDuel Research.