Kentucky vs South Alabama Prediction, Odds, Picks, Best Bets for Week 4 2026

In college football action on Saturday, the Kentucky Wildcats play the South Alabama Jaguars.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NCAA football betting odds.

Kentucky vs South Alabama Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Kentucky: (-1786) | South Alabama: (+920)
• Spread: Kentucky: -20.5 (-110) | South Alabama: +20.5 (-110)
• Total: 54.5 -- Over: (-110) | Under: (-110)

Kentucky vs South Alabama Betting Trends

• Kentucky has two wins against the spread this year.
• Kentucky is unbeaten ATS (1-0) as a 20.5-point favorite or greater this year.
• Kentucky has had two games (out of three) go over the total this year.
• South Alabama has posted two wins against the spread this year.
• Two South Alabama games (of three) have gone over the point total this year.

Kentucky vs South Alabama Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Wildcats win (90.7%)

Kentucky vs South Alabama Point Spread

Kentucky is a 20.5-point favorite against South Alabama. Kentucky is -110 to cover the spread, and South Alabama is -110.

Kentucky vs South Alabama Over/Under

The over/under for the Kentucky versus South Alabama matchup on Sept. 26 has been set at 54.5, with -110 odds on the over and -110 odds on the under.

Kentucky vs South Alabama Moneyline

The moneyline numbers for Kentucky vs. South Alabama reveal Kentucky as the favorite (-1786) and South Alabama as the underdog (+920).

Kentucky vs. South Alabama Points Insights

Kentucky vs. South Alabama Game Info

• Game day: Saturday, September 26, 2026
• Game time: 12:45 p.m. ET
• TV channel: SEC Network
• Location: Lexington, Kentucky
• Stadium: Kroger Field

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Check out even more in-depth Kentucky vs. South Alabama analysis on FanDuel Research.