Orioles vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 3:11 p.m.

MLB action on Wednesday includes the Baltimore Orioles playing the Toronto Blue Jays.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Blue Jays Game Info

• Baltimore Orioles (76-81) vs. Toronto Blue Jays (77-80)
• Date: Wednesday, September 23, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SNET

Orioles vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-126) | TOR: (+108)
• Spread: BAL: -1.5 (+172) | TOR: +1.5 (-210)
• Total: 7.5 -- Over: (+116) | Under: (-142)

Orioles vs Blue Jays Probable Starting Pitchers

Probable Pitchers: TBA (Orioles) vs TBA (Blue Jays)

Neither the Orioles nor the Blue Jays has listed a starting pitcher for this matchup.

Orioles vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (52.2%)

Orioles vs Blue Jays Moneyline

• The moneyline numbers for Orioles vs. Blue Jays reveal Baltimore as the favorite (-126) and Toronto as the underdog (+108) on the road.

Orioles vs Blue Jays Spread

• The Blue Jays are at +1.5 on the runline against the Orioles. The Blue Jays are -210 to cover the spread, and the Orioles are +172.

Orioles vs Blue Jays Over/Under

• Orioles versus Blue Jays on Sept. 23 has an over/under of 7.5 runs, with the odds on the over +116 and the under set at -142.

Bet on Baltimore Orioles vs. Toronto Blue Jays on FanDuel today!

Orioles vs Blue Jays Betting Trends

• The Orioles have been victorious in 36, or 52.9%, of the 68 contests they have been chosen as favorites in this season.
• This season Baltimore has been victorious 24 times in 47 chances when named as a favorite of at least -126 on the moneyline.
• The Orioles' games have gone over the total in 79 of their 155 opportunities.
• The Orioles are 81-74-0 against the spread in their 155 games that had a posted line this season.
• The Blue Jays have won 30 of the 69 games they were the underdog on the moneyline this season (43.5%).
• In games it has played as a moneyline underdog with odds of +108 or longer, Toronto has a 17-23 record (winning 42.5% of its games).
• The Blue Jays have had an over/under set by oddsmakers 152 times, and have combined with opponents to go over the total in 80 of those games (80-70-2).
• The Blue Jays have a 74-78-0 record against the spread this season (covering 48.7% of the time).

Orioles Player Leaders

• Pete Alonso leads Baltimore with 156 hits and an OBP of .359, plus a team-best slugging percentage of .510. He's batting .265.
• Among the qualified hitters in the majors, his batting average ranks 50th, his on-base percentage ranks 31st, and he is 11th in slugging.
• Gunnar Henderson is hitting .227 with 27 doubles, six triples, 24 home runs and 65 walks, while slugging .408 with an on-base percentage of .310.
• Among all qualified hitters, he is 119th in batting average, 103rd in on-base percentage and 83rd in slugging percentage.
• Coby Mayo is batting .227 with a .466 slugging percentage and 63 RBI this year.
• Leody Taveras has been key for Baltimore with 91 hits, an OBP of .286 plus a slugging percentage of .339.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has racked up a team-best .336 on-base percentage. He's batting .263 and slugging .359.
• Including all the qualifying hitters in MLB, his batting average puts him 55th, his on-base percentage ranks 60th, and he is 121st in slugging.
• Guerrero enters this game on a four-game hitting streak. During his last five outings he is hitting .267 with three walks.
• Kazuma Okamoto's 130 hits pace his team. He has a batting average of .235 while slugging .458 with an on-base percentage of .310.
• He ranks 103rd in batting average, 103rd in on-base percentage and 38th in slugging percentage in MLB.
• Ernie Clement has put up a team-high .370 slugging percentage.
• George Springer is batting .251 with 22 doubles, two triples, 15 home runs and 47 walks.

Orioles vs Blue Jays Head to Head

• 9/13/2026: 8-1 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/12/2026: 7-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/11/2026: 7-4 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/7/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/6/2026: 6-4 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/5/2026: 13-3 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/31/2026: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/30/2026: 6-5 BAL (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/29/2026: 6-5 TOR (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/28/2026: 2-1 TOR (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!