Northwestern vs UCLA Prediction, Odds, Picks, Best Bets for Week 5 2025

The Northwestern Wildcats will take on the UCLA Bruins in college football action on Saturday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Northwestern vs UCLA Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Northwestern: (-220) | UCLA: (+180)
• Spread: Northwestern: -5.5 (-120) | UCLA: +5.5 (-102)
• Total: 45.5 -- Over: (-112) | Under: (-108)

Northwestern vs UCLA Betting Trends

• Northwestern has posted two wins against the spread this season.
• Northwestern has covered every time (1-0) as a 5.5-point favorite or greater this year.
• No Northwestern game has gone over the point total this year.
• UCLA is winless against the spread this year.
• UCLA doesn't have a win ATS (0-1) as a 5.5-point underdog or more this season.
• One of UCLA's three games has hit the over.

Northwestern vs UCLA Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Wildcats win (56.9%)

Northwestern vs UCLA Point Spread

UCLA is listed as an underdog by 5.5 points (-102 odds), and Northwestern, the favorite, is -120 to cover.

Northwestern vs UCLA Over/Under

Northwestern versus UCLA on Sept. 27 has an over/under of 45.5 points, with the over -112 and the under -108.

Northwestern vs UCLA Moneyline

Looking at the moneyline for UCLA-Northwestern, UCLA is the underdog at +180, and Northwestern is -220.

Northwestern vs. UCLA Points Insights

Northwestern vs. UCLA Game Info

• Game day: Saturday, September 27, 2025
• Game time: 3:30 p.m. ET
• TV channel: BTN
• Location: Evanston, Illinois
• Stadium: Northwestern Medicine Field at Martin Stadium

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Check out even more in-depth Northwestern vs. UCLA analysis on FanDuel Research.