Arizona Cardinals Vs. San Francisco 49ers Odds, Betting Lines, Score & Stats (September 27, 2026)

Featured Player Props

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Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Popular Bets

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4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

Top Projected Fantasy Performers

Arizona Cardinals

15.7 Points

12.5 Points

9.0 Points

8.6 Points

San Francisco 49ers

QBBrock Purdy

20.8 Points

RBChristian McCaffrey

18.3 Points

WRMike Evans

10.8 Points

TEGeorge Kittle

8.2 Points

Injuries

Arizona Cardinals

NameStatus

RBJames Conner

QFoot

OLBJosh Sweat

PUPKnee

TEKenny Yeboah

IRHamstring

DTZach Carter

QKnee

SAFJoey Blount

IRNeck

CBGarrett Williams

PUPAchilles

San Francisco 49ers

NameStatus

WRMike Evans

QQuadriceps

FBKyle Juszczyk

QFinger

TEGeorge Kittle

PUPAchilles

LBLuke Gifford

QHamstring

RBChristian McCaffrey

QUndisclosed

WRChristian Kirk

QCalf

Team Stats

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ARI

Offensive EPA

Passing EPA

Rushing EPA

Defensive EPA

Def Pass EPA

Def Rush EPA

Game Log

Arizona Cardinals

DateOpponentResultSpread

San Francisco 49ers

DateOpponentResultSpread

Popular Bets

Odds not available yet.

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4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

Odds not available yet.

Check back closer to game time!

Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Line Movement

These graphs show how the spread, moneyline, and total have shifted at FanDuel Sportsbook over time.

Spread

Cardinals

Open: -

49ers

Open: -

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Moneyline

Cardinals

Open: -

49ers

Open: -

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Total

Over

Open: -

Under

Open: -

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Arizona Cardinals

15.7 Points

12.5 Points

9.0 Points

8.6 Points

San Francisco 49ers

QBBrock Purdy

20.8 Points

RBChristian McCaffrey

18.3 Points

WRMike Evans

10.8 Points

TEGeorge Kittle

8.2 Points

Arizona Cardinals

NameStatus

RBJames Conner

QFoot

OLBJosh Sweat

PUPKnee

TEKenny Yeboah

IRHamstring

DTZach Carter

QKnee

SAFJoey Blount

IRNeck

CBGarrett Williams

PUPAchilles

San Francisco 49ers

NameStatus

WRMike Evans

QQuadriceps

FBKyle Juszczyk

QFinger

TEGeorge Kittle

PUPAchilles

LBLuke Gifford

QHamstring

RBChristian McCaffrey

QUndisclosed

WRChristian Kirk

QCalf

FOX

Arizona Cardinals

0-0 | 0th in NFC West | 0th in NFC

SpreadMoneylineTotal

San Francisco 49ers

0-0 | 0th in NFC West | 0th in NFC

SpreadMoneylineTotal

FOX

Levi's Stadium

4 Leg Parlay HelpCircle

Player

Player 40+ Yards

Player 250+ Yards

Player 5+ Receptions

4 Leg Parlay HelpCircle

Player

Player 40+ Yards

Player 250+ Yards

Player 5+ Receptions

NFL

More NFL Games

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Player

Player 40+ Yards

Player 250+ Yards

Player 5+ Receptions

4 Leg Parlay HelpCircle

Player

Player 40+ Yards

Player 250+ Yards

Player 5+ Receptions

Spread

Moneyline

Total

NFL

4 Leg Parlay

4 Leg Parlay

4 Leg Parlay

4 Leg Parlay