Detroit Lions Vs. Buffalo Bills Odds, Betting Lines, Score & Stats (September 17, 2026)

Featured Player Props

View all NFL Player Props

Odds not available yet.

Check back closer to game time!

Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Popular Bets

Odds not available yet.

Check back closer to game time!

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

Featured Promos

View all Promos

Top Projected Fantasy Performers

Detroit Lions

Buffalo Bills

Injuries

Detroit Lions

NameStatus

Buffalo Bills

NameStatus

Team Stats

View all Team Stats

DET

BUF

Offensive EPA

Passing EPA

Rushing EPA

Defensive EPA

Def Pass EPA

Def Rush EPA

NFL

Thursday Night Football Schedule for 2026: Full List of TNF Games

10d

Every Thursday Night Football game for the 2026 season.

Monday Night Football Schedule for 2026: Full List of MNF Games

10d

NFL Week 1 Schedule 2026: Odds, Spreads, Moneylines, and Totals for Every Game

10d

2026 NFL Schedule Release: Home and Away Games for Each Team With FanDuel Win Total Odds

11d

NFL 2026 Schedule Release: How Miles Traveled Impacts Playoff Odds and Super Bowl Chances

11d

NFL Schedule 2026: Full Schedule of International Games With Betting Odds

12d

Dynasty Fantasy Football Rookie Rankings for 2026 Rookie Drafts

28d

2026 NFL Draft Reaction: Draft Grades for Every Team

28d

2026 NFL Draft Recap: A List of Every Pick From This Year's NFL Draft

28d

NFL Draft Grades for the First Round: Assigning a Grade to Every Pick

1mo

NFL Rookie Prop Bets: Best Bets for Rookie Passing, Rushing and Receiving Props

1mo

More NFL Games

Popular Bets

Odds not available yet.

Check back closer to game time!

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

Detroit Lions

DateOpponentResultSpread

Buffalo Bills

DateOpponentResultSpread

Odds not available yet.

Check back closer to game time!

Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Detroit Lions

Buffalo Bills

Detroit Lions

NameStatus

Buffalo Bills

NameStatus

Line Movement

These graphs show how the spread, moneyline, and total have shifted at FanDuel Sportsbook over time.

Spread

Lions

Open: -

Bills

Open: -

Odds not available yet.

Check back closer to game time!

Moneyline

Lions

Open: -

Bills

Open: -

Odds not available yet.

Check back closer to game time!

Total

Over

Open: -

Under

Open: -

Odds not available yet.

Check back closer to game time!

DET

BUF

Offensive EPA

Passing EPA

Rushing EPA

Defensive EPA

Def Pass EPA

Def Rush EPA

Detroit Lions

DateOpponentResultSpread

Buffalo Bills

DateOpponentResultSpread

Detroit Lions

9-8 | 4th in NFC North | 9th in NFC

SpreadMoneylineTotal

Buffalo Bills

12-5 | 2nd in AFC East | 6th in AFC

SpreadMoneylineTotal

4 Leg Parlay HelpCircle

Player

Player 40+ Yards

Player 250+ Yards

Player 5+ Receptions

4 Leg Parlay HelpCircle

Player

Player 40+ Yards

Player 250+ Yards

Player 5+ Receptions

NFL

More NFL Games

4 Leg Parlay HelpCircle

Player

Player 40+ Yards

Player 250+ Yards

Player 5+ Receptions

4 Leg Parlay HelpCircle

Player

Player 40+ Yards

Player 250+ Yards

Player 5+ Receptions

Spread

Moneyline

Total

NFL

4 Leg Parlay

4 Leg Parlay

4 Leg Parlay

4 Leg Parlay