NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 6

The Chicago Bears versus the Atlanta Falcons is a game to see on a Week 6 NFL slate that features a lot of thrilling contests.

Read through our betting breakdown for the NFL's Week 6.

Broncos vs. Seahawks

Jaxon Smith-Njigba will lead the Seattle Seahawks (3-2) into their matchup versus the Denver Broncos (3-2) at Empower Field at Mile High on Thursday at 8:15 p.m. ET.

• Game Preview: Seattle Seahawks at Denver Broncos
• Projected Favorite: Seahawks (61.69% win probability)
• Spread: Seattle (-2.5)
• Total: 40.5 -- Over: (-115) | Under: (-105)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Denver vs. Seattle with FanDuel Sportsbook.

Jaguars vs. Texans

The Jacksonville Jaguars (4-1) and their 23rd-ranked pass defense may struggle to stop the Houston Texans (1-4) and C.J. Stroud, one of the league's top passers, when the Jaguars host the Texans at Wembley Stadium on Oct. 18 at 9:30 a.m. ET.

• Game Preview: Houston Texans vs. Jacksonville Jaguars
• Projected Favorite: Jaguars (60.81% win probability)
• Spread: Jacksonville (-2.5)
• Total: 42.5 -- Over: (-112) | Under: (-108)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Jacksonville vs. Houston with FanDuel Sportsbook.

Giants vs. Saints

The New Orleans Saints (1-4), who were taken down by the Vikings in their previous tilt 23-13, visit the New York Giants (3-1-1) at MetLife Stadium on Oct. 18 at 1 p.m. ET. The Giants tied the Commanders 27-27 in their last outing.

• Game Preview: New Orleans Saints at New York Giants
• Projected Favorite: Giants (53.72% win probability)
• Spread: New Orleans (-1.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. New Orleans with FanDuel Sportsbook.

Buccaneers vs. Steelers

One of the best pass-catchers in football will be on show when Jaylen Warren and the Pittsburgh Steelers (3-2) visit the Tampa Bay Buccaneers (1-4) on Sunday, October 18, 2026.

• Game Preview: Pittsburgh Steelers at Tampa Bay Buccaneers
• Projected Favorite: Steelers (54.21% win probability)
• Spread: Pittsburgh (-2.5)
• Total: 39.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tampa Bay vs. Pittsburgh with FanDuel Sportsbook.

Colts vs. Titans

Star running back Jonathan Taylor and the Indianapolis Colts (2-3) meet the Tennessee Titans (0-5) on Sunday at 1 p.m. ET at Lucas Oil Stadium.

• Game Preview: Tennessee Titans at Indianapolis Colts
• Projected Favorite: Colts (78.56% win probability)
• Spread: Indianapolis (-6.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Indianapolis vs. Tennessee with FanDuel Sportsbook.

Browns vs. Ravens

The Baltimore Ravens (4-1), who took down the Falcons in their previous game, visit the Cleveland Browns (3-2) at Huntington Bank Field on Oct. 18 at 1 p.m. ET. The Browns lost to the Jets in their last game.

• Game Preview: Baltimore Ravens at Cleveland Browns
• Projected Favorite: Ravens (61.27% win probability)
• Spread: Baltimore (-4.5)
• Total: 41.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Baltimore with FanDuel Sportsbook.

Falcons vs. Bears

One of the best running backs in football will be featured when Bijan Robinson and the Atlanta Falcons (2-3) host the Chicago Bears (3-2) on Sunday, October 18, 2026.

• Game Preview: Chicago Bears at Atlanta Falcons
• Projected Favorite: Bears (52.87% win probability)
• Spread: Chicago (-3)
• Total: 49.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Atlanta vs. Chicago with FanDuel Sportsbook.

Patriots vs. Jets

One of the best pass-catchers in football will be featured when Garrett Wilson and the New York Jets (2-3) visit the New England Patriots (3-2) on Sunday, October 18, 2026.

• Game Preview: New York Jets at New England Patriots
• Projected Favorite: Patriots (86.88% win probability)
• Spread: New England (-7.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. New York with FanDuel Sportsbook.

Eagles vs. Panthers

On Sunday, Oct. 18 at 1 p.m. ET, the Philadelphia Eagles (2-3) and their 29th-ranked scoring offense (18.4 points per game) will square off against the Carolina Panthers (2-2) and their fourth-ranked offense (30.3 points per game).

• Game Preview: Carolina Panthers at Philadelphia Eagles
• Projected Favorite: Panthers (61.93% win probability)
• Spread: Philadelphia (-1.5)
• Total: 41.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Philadelphia vs. Carolina with FanDuel Sportsbook.

Rams vs. Cardinals

The Los Angeles Rams (2-3), who lost to the Bills in their last game, host the Arizona Cardinals (1-4) at SoFi Stadium on Oct. 18 at 4:05 p.m. ET. The Cardinals lost to the Lions in their last game.

• Game Preview: Arizona Cardinals at Los Angeles Rams
• Projected Favorite: Rams (89.63% win probability)
• Spread: Los Angeles (-12.5)
• Total: 51.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Arizona with FanDuel Sportsbook.

Raiders vs. Bills

Two of the top offensive players in football will be featured when running back James Cook and the Buffalo Bills (4-1) visit Brock Bowers and the Las Vegas Raiders (3-2) on Sunday, October 18, 2026.

• Game Preview: Buffalo Bills at Las Vegas Raiders
• Projected Favorite: Bills (68.45% win probability)
• Spread: Buffalo (-5.5)
• Total: 53.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Buffalo with FanDuel Sportsbook.

Chiefs vs. Chargers

Kenneth Walker III will lead the Kansas City Chiefs (4-0) into their battle against the Los Angeles Chargers (0-5) at GEHA Field at Arrowhead Stadium on Sunday at 4:25 p.m. ET.

• Game Preview: Los Angeles Chargers at Kansas City Chiefs
• Projected Favorite: Chiefs (86.15% win probability)
• Spread: Kansas City (-8.5)
• Total: 42.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Kansas City vs. Los Angeles with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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