Steelers vs Buccaneers Prediction, Odds, Picks, Best Bets for NFL Week 6

The NFL's Sunday schedule includes the Pittsburgh Steelers taking on the Tampa Bay Buccaneers.

All the info you need is below, in order to make a smart bet on this matchup at FanDuel Sportsbook.

Steelers vs Buccaneers Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Steelers win (54.2%)

Steelers vs Buccaneers Point Spread

The Steelers are 2.5-point favorites against the Buccaneers. The Steelers are -115 to cover the spread, while the Buccaneers are -105 to cover as a 2.5-point underdog.

Steelers vs Buccaneers Over/Under

Steelers versus Buccaneers, on Oct. 18, has an over/under of 40.5, with the over being -106 and the under -114.

Steelers vs Buccaneers Moneyline

Pittsburgh is the favorite, -144 on the moneyline, while Tampa Bay is a +122 underdog despite being at home.

Steelers vs Buccaneers Betting Trends

• Pittsburgh's record against the spread is 3-2-0.
• The Steelers have two wins ATS (2-1) as a 2.5-point favorite or greater this season.
• The Steelers have played five games this year and three of them have hit the over.
• The Buccaneers have posted one win against the spread this season.
• Tampa Bay has one win ATS (1-1-1) as a 2.5-point underdog or more this year.
• Two of the Buccaneers' five games in 2026 have gone over the point total.

Check out even more in-depth Steelers vs. Buccaneers analysis on FanDuel Research.

Steelers vs Buccaneers Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-144) | TB: (+122)
• Spread: PIT: -2.5 (-115) | TB: +2.5 (-105)
• Total: 40.5 -- Over: (-106) | Under: (-114)

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