Saints vs Giants Prediction, Odds, Picks, Best Bets for NFL Week 6

The Sunday schedule in the NFL includes a matchup between the New Orleans Saints and the New York Giants.

Before you place your bet on this game at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

Saints vs Giants Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Giants win (53.7%)

Saints vs Giants Point Spread

The Saints are 1.5-point favorites against the Giants. The Saints are +100 to cover the spread, while the Giants are -122 to cover as a 1.5-point underdog.

Saints vs Giants Over/Under

The over/under for Saints-Giants on Oct. 18 is 45.5. The over is -110, and the under is -110.

Saints vs Giants Moneyline

New York is the underdog, -106 on the moneyline, while New Orleans is a -110 favorite despite being on the road.

Saints vs Giants Betting Trends

• New Orleans has posted two wins against the spread this year.
• The Saints are winless ATS (0-2) when playing as at least 1.5-point favorites this year.
• The Saints have seen three of their five games go over the point total.
• The Giants' record against the spread is 4-1-0.
• New York is 3-1 as 1.5-point or bigger underdogs in 2026.
• The Giants have played five games this season, and three of them have gone over the total.

Check out even more in-depth Saints vs. Giants analysis on FanDuel Research.

Saints vs Giants Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NO: (-110) | NYG: (-106)
• Spread: NO: -1.5 (100) | NYG: +1.5 (-122)
• Total: 45.5 -- Over: (-110) | Under: (-110)

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